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  1. ...repeats from the Monodelphis . They cover ∼52% of the genome, higher than in any other amniotic lineage studied to date, and may account for the unusually large genome size. In comparison to other mammals, Monodelphis is significantly rich in non-LTR retrotransposons from the LINE-1, CR1, and RTE...
  2. .... 2003 . The birth of an alternatively spliced exon: 3′ splice-site selection in Alu exons. Science 300 : 1288 -1291. ↵ Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S., and Mignot, E. 1999 . The sleep disorder canine narcolepsy is caused by a mutation...
  3. ...( Whitelaw and Martin 2001 ). AR sequences can introduce new splice sites, protein domains, stop codons, and other sequences and can split genes, leading to the birth of new genes or alternative isoforms ( Smit 1999 ; Lev-Maor et al. 2003 ; Yi et al. 2003 ; Dagan et al. 2004 ; Brandt et al. 2005a , b ; Krull...
  4. ...not associated with other genes. We detected 88–280 selectively preserved retrocopies per mammalian species, illustrating that these mechanisms facilitated the birth of many functional retrogenes during mammalian evolution. The regulatory evolution of originally monoexonic retrocopies was frequently accompanied...
  5. ...that must precede the birth and fixation of a new protein-coding gene from an ancestrally noncoding DNA region (Fig. 3): (1) The DNA must become transcriptionally active, and (2) it must also evolve a translatable open reading frame that encodes a potentially beneficial protein. The former may be readily...
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