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  1. .... , Westbrook C.A. ( 1998 ) Modification of bacterial artificial chromosome clones using Cre recombinase: Introduction of selectable markers for expression in eukaryotic cells. Genome Res. 8 : 404 – 412 . ↵ Liu Q. , Li M.Z. , Leibham D. , Cortez D. , Elledge S.J. ( 1998 ) The univector plasmid-fusion system...
  2. ...from large chromosomal aberrations, such as translocations, inversions, deletions, or duplications, tomore subtle modifications like point mutations in particular CREs (Epstein 2009; Kleinjan and Coutinho 2009; Kilpinen and Dermitzakis 2012). Since these diseases are caused by improper gene regulation...
  3. ...the loss of one allele at the targeted locus. We tried this with ES cells that were electroporated with the N1::CreERT2 construct. Homologous recombination will replace the Notch1 intracellular domain with DNA encoding CreERT2 and a FRT flanked selective marker; hence, only one wild-type allele remains...
  4. ...in mammalian cells by the cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. 85: 5166 – 5170. Sax, K. Sax, K. 1923. The association of size differences with seed-coat pattern and pigmentation in Phaseolus vulgaris . Genetics 8: 552 – 560. Schon, C.C., , Melchinger, A.E. , Boppenmaier, J. , Brunklaus...
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