Searching journal content for articles similar to Kim et al. 10 (8): 1138.

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  1. ...) region, highlighting how this chromosomal rearrangement can impact the transcriptional landscape throughout the . We recognize that, even in an isogenic background, some of these gene expression changes could occur owing to the single-cell cloning process or as a consequence of missegregating Chromosome...
  2. ...”) number and subsequent divergence of function (Hahn 2009).Approximately 75% of lung cancers have WGD events during their evolutionary history (Jamal-Hanjani et al. 2017). Furthermore, changes in gene copy number owing to aneuploidy, in which chromosomes or chromosomal regions are gained or lost, represent...
  3. ...) gene, while the expansion of a GGGGCC repeat intronic of C9orf72 gene has been linked to increased risk of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (Pandolfo 2009; DeJesus-Hernandez et al. 2011). VNTR expansions have also been implicated in several diseases (De Roeck et al...
  4. ...expression in biological systems. At the core of these networks lies the inference of gene regulation, which reflects the binding of transcription factors (TFs) to specific DNA sequences to either activate or repress target gene expression. This regulation directs crucial cellular processes...
  5. ...). Additionally, chromatin 44 3 organization dictates the proximity of genes to regulatory elements (Djebali et al. 2012; 45 Grubert et al. 2020; Vierstra et al. 2020). The abundance and quality of synthesized 46 RNAs are then regulated through different processing and degradation pathways in the 47 nucleus...
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  6. .... Shown are heatmaps of the log2 fold enrichment (FE) and negative log10 false-discovery rate (FDR) results from the GO analysis. (E,F) GO results for the significantly differentially expressed genes in CySC-like and GSC-like cells. Shown are heatmaps of the log2FE and negative log10FDR results from...
  7. ...The grasshopper reveals long-term gene content conservation of the X Chromosome and temporal variation in X Chromosome evolution Xinghua Li1,2, Judith E. Mank3 and Liping Ban1 1Department of Grassland Resources and Ecology, College of Grassland Science and Technology, China Agricultural University...
  8. .... Genes that control the characteristic color traits could be genetically mapped on the X and Y Chromosomes (Winge 1922; Khoo et al. 1999; Lindholm and Breden 2002; Tripathi et al. 2009a). A genetic map based on EST- and BAC-derived markers was generated, and LG12 was identified as the sex chromosome...
  9. ...regulation. By critically examining both established tools and emerging techniques such as editing, synthetic chromosomes, and high-resolution imaging, we provide a practical framework for investigators seeking to uncover direct regulators of specific genes. Our goal is to guide the design of experiments...
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  10. ...upstream sequence imparts a multifaceted role in regulation beyond the XCI.X-Chromosome inactivation (XCI) is a process by which female mammals compensate for the dosage of X-linked gene expression between sexes (Lyon 1961; Gayen et al. 2015, 2016). XCI is an excellent model system for understanding...
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