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  1. ...data, many experimentally testable hypotheses that describe the metabolic and regulatory networks of Halobacterium NRC-1. Biological systems have evolved mechanisms to appropriately respond to environmental stresses that can damage proteins and DNA. Halobacterium NRC-1 , for example, has evolved...
  2. ...environmental response system Photobiology: opsins, cryptochrome/photolyase, clock regulators, and transducers Similar to Halobacterium sp . NRC-1, H. marismortui inhabits an extreme environment characterized by high salt concentration, low oxygen solubility, and high light intensity. An evolutionary adaptation...
  3. .... Biopolymers 22 : 2577 -2637. ↵ Karner, M.B., DeLong, E.F., and Karl, D.M. 2001 . Archaeal dominance in the mesopelagic zone of the Pacific Ocean. Nature 409 : 507 -510. ↵ Kennedy, S.P., Ng, W.V., Salzberg, S.L., Hood, L., and DasSarma, S. 2001 . Understanding the adaptation of Halobacterium species NRC-1...
  4. ...and the optimal growth temperature is found among the sequenced thermophiles. It is concluded that thermophiles are a biologically and phylogenetically divergent group of prokaryotes that have converged to sustain extreme environmental conditions over evolutionary timescale. [Supplemental material is available...
  5. ...for the conventional two-step oxidation of GAP, these enzymes in Thermococcales have been proposed to act in the gluconeogenic direction. T. kodakaraensis and a limited number of other archaea ( P. furiosus, Sulfolobus spp., Aeropyrum pernix , and Halobacterium sp. NRC-1) possess orthologs for GAP dehydrogenase...
  6. ...of stress against other stressors (Jenkins et al. 1988; Lu et al. 2009). Conversely, cells also induce stress-specific responses to aid survival for a particular condition (Stephen et al. 1995; Zuber 2009). The hypersaline-adapted, or halophilic, archaeon Halobacterium salinarum is a model organism uniquely...
  7. ...candidate for such global analysis is Halobacterium NRC-1, an archaeon that thrives in a >4.0 M salinity environment. This halophile is easily cultured and manipulated in the laboratory and has a range of systems-analysis tools available for its inquiry ( Weston et al. 2003 ). In this report, we describe...
  8. ...unreachable by homology modeling. Unfortunately, de novo prediction methods require vast computational resources, and because of this, published pipelines that include de novo structure prediction are incapable of keeping pace with incoming genomic data. This study focuses on this fourth type of annotation...
  9. ...across these distinct but interconnected processes remain to be characterized to build a physiological model of systems behavior. We chose the haloarchaeon Halobacterium salinarum NRC-1 as a model organism to investigate the systems-level oxygen response. This organism, found in the Great Salt Lake...
  10. ...to be a general feature of most Eubacteria. These results are not inconsistent with the findings of Workman and Krogh ( 1999 ), as only 2 of 46 sequences in their analyses came from Eubacteria. Two of eight Archaea studied, the thermophiles M. thermoautotropicum and Halobacterium sp. NRC-1, exhibited...
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