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LETTER: Evolutionary constraints in conserved nongenic sequences of mammals
- Peter D. Keightley,
- Gregory V. Kryukov,
- Shamil Sunyaev,
- Daniel L. Halligan,
- and Daniel J. Gaffney
Genome Res. October 2005 15: 1373-1378; doi:10.1101/gr.3942005
.... Deleterious mutations and the evolution of sex. Science 290 : 331 -333. ↵ Keightley, P.D. and Johnson, T. 2004 . MCALIGN: Stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution. Genome Res. 14 : 442 -450. ↵ Keightley, P.D., Lercher, M.J., and Eyre-Walker, A. 2005...
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LETTER: Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison
- Daniel L. Halligan and
- Peter D. Keightley
Genome Res. July 2006 16: 875-884; Published in Advance June 2, 2006, doi:10.1101/gr.5022906
...is an improved version of MCALIGN ( Keightley and Johnson 2004 ) that uses a procedure that attempts to find the most probable alignment according to a specific model of insertion–deletion evolution; a model suitable for Drosophila non-coding DNA was chosen ( Keightley and Johnson 2004 ). Coding DNA sequences...

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