Searching journal content for articles similar to Karnani et al. 17 (6): 865.

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  1. Research: Chromatin signatures of the Drosophila replication program
    • Matthew L. Eaton,
    • Joseph A. Prinz,
    • Heather K. MacAlpine,
    • George Tretyakov,
    • Peter V. Kharchenko,
    • and David M. MacAlpine
    Genome Res. February 2011 21: 164-174; Published in Advance December 22, 2010, doi:10.1101/gr.116038.110
    ..., they represent some of the most commonly utilized cell lines in the Drosophila research community. We have taken a top-down approach, characterizing the replication program by utilizing increasingly high-resolution and complementary assays (Fig. 1A). Specifically, we used genomic tiling arrays to determine...
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  2. Research: Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription
    • Larry D. Mesner,
    • Veena Valsakumar,
    • Neerja Karnani,
    • Anindya Dutta,
    • Joyce L. Hamlin,
    • and Stefan Bekiranov
    Genome Res. March 2011 21: 377-389; Published in Advance December 20, 2010, doi:10.1101/gr.111328.110
    ...tiling arrays, these libraries illuminated 15.3%, 16.4%, and 21.8% of the genome in the ENCODE regions, respectively. Approximately half of the origin fragments cluster into zones, and their signals are generally higher than those of isolated fragments. Interestingly, initiation events are distributed...
  3. Letter: Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading
    • Heather K. MacAlpine,
    • Raluca Gordân,
    • Sara K. Powell,
    • Alexander J. Hartemink,
    • and David M. MacAlpine
    Genome Res. February 2010 20: 201-211; Published in Advance December 7, 2009, doi:10.1101/gr.097873.109
    .... 1B). ORC specifically localizes to early activating origins, providing an important biological validation of our ORC mapping using genomic arrays. In order to duplicate the completely during S phase, multiple start sites of DNA replication must be distributed across each chromosome. We sought...
  4. Research: Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins
    • Larry D. Mesner,
    • Veena Valsakumar,
    • Marcin Cieślik,
    • Rebecca Pickin,
    • Joyce L. Hamlin,
    • and Stefan Bekiranov
    Genome Res. November 2013 23: 1774-1788; Published in Advance July 16, 2013, doi:10.1101/gr.155218.113
    ....17 corresponds to equal amounts of DNA replicated in each one of the six time intervals (a so-called pan-S replication pattern) ( Jeon et al. 2005; Karnani et al. 2007). Raw replication timing data for the six S-phase intervals (G1b, S1–4, and G2) are shown in Supplemental Figure S2. Also shown are the smoothed...
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