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Editorial: Long reads decipher genomes and transcriptomes and offer novel insights into biology and diseases
- Ana Conesa,
- Alexander Hoischen,
- and Fritz J. Sedlazeck
Genome Res. April 2025 35: xi-xiv; doi:10.1101/gr.280665.125
.... 2025 . Heterogeneous and novel transcript expression in single cells of patient-derived clear cell renal cell carcinoma organoids . Genome Res (this issue) 35 : 698 – 711 . doi: 10.1101/gr.279345.124 ↵ Keil N , Monzó C , McIntyre L , Conesa A . 2025 . Quality assessment of long read data in multisample...
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Perspective: Unraveling the hidden complexity of cancer through long-read sequencing
- Qiuhui Li,
- Ayse G. Keskus,
- Justin Wagner,
- Michal B. Izydorczyk,
- Winston Timp,
- Fritz J. Sedlazeck,
- Alison P. Klein,
- Justin M. Zook,
- Mikhail Kolmogorov,
- and Michael C. Schatz
Genome Res. April 2025 35: 599-620; Published in Advance March 20, 2025, doi:10.1101/gr.280041.124
...technologies for SV discovery in breast cancer patients-derived organoids.More recent studies demonstrated the feasibility of producing long-read sequencing from various clinical tumor samples. For example, Sakamoto et al. (2020b) characterized regions of clustered copy number changes, inversions...
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Perspective: Cancer cell states and emergent properties of the dynamic tumor system
- Dalia Barkley,
- Anjali Rao,
- Maayan Pour,
- Gustavo S. França,
- and Itai Yanai
Genome Res. October 2021 31: 1719-1727; doi:10.1101/gr.275308.121
.... Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening. Nat Commun 10: 3991. doi:10.1038/s41467-019-11867-6 Kim N, Kim HK, Lee K, Hong Y, Cho JH, Choi JW, Lee J-I, Suh Y-L, Ku BM, Eum HH, et al. 2020. Single-cell RNA sequencing demonstrates the molecular and cellular...

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