Searching journal content for articles similar to Kan et al. 23 (9): 1422.

Displaying results 1-10 of 17

For checked items

view abstracts
download to citation manager

Select this article
Method: Nanopore sequencing identifies high-frequency somatic structural variations in laryngeal squamous cell carcinoma genomes
- Xuyan Liu,
- Lin Xia,
- Yixin Qiao,
- Yang Li,
- Yan Huang,
- Bingyan Yue,
- Xi Liang,
- Xin Yang,
- Honghui Zhang,
- Jiaxun Zhang,
- Xiao Chen,
- Dan Xie,
- and Jifeng Liu
Genome Res. April 8, 2026 gr.281046.125; Published in Advance April 8, 2026, doi:10.1101/gr.281046.125
...Nanopore sequencing identifies high-frequency somatic structural 1 variations in laryngeal squamous cell carcinoma s 2 Xuyan Liu1#, Lin Xia1#, Yixin Qiao2#, Yang Li1, Yan Huang1, Bingyan Yue2, Xi Liang2, Xin 3 Yang2, Honghui Zhang2, Jiaxun Zhang1, Xiao Chen1, Dan Xie1*, Jifeng Liu2,3* 4 1...
- Abstract
- Full Text (PDF)
OPEN ACCESS ARTICLEACCEPTED MANUSCRIPT
Select this article
Research: Multisite long-read sequencing reveals the early contributions of somatic structural variations to HBV-related hepatocellular carcinoma tumorigenesis
- Tianfu Zeng,
- Haotian Liao,
- Lin Xia,
- Siyao You,
- Yanqun Huang,
- Jiaxun Zhang,
- Yahui Liu,
- Xuyan Liu,
- and Dan Xie
Genome Res. April 2025 35: 671-685; Published in Advance March 4, 2025, doi:10.1101/gr.279617.124
...↵3 These authors equally contributed to this work. Corresponding author: danxie@scu.edu.cnAbstractSomatic structural variations (SVs) represent a critical category of genomic mutations in hepatocellular carcinoma (HCC). However, the accurate identification of somatic SVs using short-read high...
OPEN ACCESS ARTICLE
Select this article
Perspective: Unraveling the hidden complexity of cancer through long-read sequencing
- Qiuhui Li,
- Ayse G. Keskus,
- Justin Wagner,
- Michal B. Izydorczyk,
- Winston Timp,
- Fritz J. Sedlazeck,
- Alison P. Klein,
- Justin M. Zook,
- Mikhail Kolmogorov,
- and Michael C. Schatz
Genome Res. April 2025 35: 599-620; Published in Advance March 20, 2025, doi:10.1101/gr.280041.124
...leading to the clonal evolution of cancer cells (Qing et al. 2020; Chakravarty and Solit 2021). Somatic mutations in key genes and their regulatory sequences, especially oncogenes, tumor suppressors, and DNA repair genes, are frequently found in cancers and contribute to tumor progression and therapeutic...
OPEN ACCESS ARTICLE
Select this article
Research: Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing
- Elena Helman,
- Michael S. Lawrence,
- Chip Stewart,
- Carrie Sougnez,
- Gad Getz,
- and Matthew Meyerson
Genome Res. July 2014 24: 1053-1063; Published in Advance May 13, 2014, doi:10.1101/gr.163659.113
...source of genetic variation, and somatic retrotransposon insertions have been reported in cancer. Here, we applied TranspoSeq, a computational framework that identifies retrotransposon insertions from sequencing data, to whole genomes from 200 tumor/normal pairs across 11 tumor types as part...
Select this article
Research: C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
- Bettina Meier,
- Susanna L. Cooke,
- Joerg Weiss,
- Aymeric P. Bailly,
- Ludmil B. Alexandrov,
- John Marshall,
- Keiran Raine,
- Mark Maddison,
- Elizabeth Anderson,
- Michael R. Stratton,
- Anton Gartner,
- and Peter J. Campbell
Genome Res. October 2014 24: 1624-1636; Published in Advance July 16, 2014, doi:10.1101/gr.175547.114
...C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency Bettina Meier 1 , 6 , Susanna L. Cooke 2 , 6 , Joerg Weiss 1 , Aymeric P. Bailly 1 , 3 , Ludmil B. Alexandrov...
OPEN ACCESS ARTICLE
Select this article
Research: Whole genome sequencing of matched primary and metastatic acral melanomas
- Samra Turajlic,
- Simon J. Furney,
- Maryou B. Lambros,
- Costas Mitsopoulos,
- Iwanka Kozarewa,
- Felipe C. Geyer,
- Alan MacKay,
- Jarle Hakas,
- Marketa Zvelebil,
- Christopher J. Lord,
- Alan Ashworth,
- Meirion Thomas,
- Gordon Stamp,
- James Larkin,
- Jorge S. Reis-Filho,
- and Richard Marais
Genome Res. February 2012 22: 196-207; Published in Advance December 19, 2011, doi:10.1101/gr.125591.111
...Next generation sequencing has enabled systematic discovery of mutational spectra in cancer samples. Here, we used whole genome sequencing to characterize somatic mutations and structural variation in a primary acral melanoma and its lymph node metastasis. Our data show that the somatic mutational...
OPEN ACCESS ARTICLE
Select this article
Research: Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
- Keiko Akagi,
- Jingfeng Li,
- Tatevik R. Broutian,
- Hesed Padilla-Nash,
- Weihong Xiao,
- Bo Jiang,
- James W. Rocco,
- Theodoros N. Teknos,
- Bhavna Kumar,
- Danny Wangsa,
- Dandan He,
- Thomas Ried,
- David E. Symer,
- and Maura L. Gillison
Genome Res. February 2014 24: 185-199; Published in Advance November 7, 2013, doi:10.1101/gr.164806.113
...genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of “looping...
Select this article
Research: Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
- Jinfeng Liu,
- William Lee,
- Zhaoshi Jiang,
- Zhongqiang Chen,
- Suchit Jhunjhunwala,
- Peter M. Haverty,
- Florian Gnad,
- Yinghui Guan,
- Houston N. Gilbert,
- Jeremy Stinson,
- Christiaan Klijn,
- Joseph Guillory,
- Deepali Bhatt,
- Steffan Vartanian,
- Kimberly Walter,
- Jocelyn Chan,
- Thomas Holcomb,
- Peter Dijkgraaf,
- Stephanie Johnson,
- Julie Koeman,
- John D. Minna,
- Adi F. Gazdar,
- Howard M. Stern,
- Klaus P. Hoeflich,
- Thomas D. Wu,
- Jeff Settleman,
- Frederic J. de Sauvage,
- Robert C. Gentleman,
- Richard M. Neve,
- David Stokoe,
- Zora Modrusan,
- Somasekar Seshagiri,
- David S. Shames,
- and Zemin Zhang
Genome Res. December 2012 22: 2315-2327; Published in Advance October 2, 2012, doi:10.1101/gr.140988.112
...is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell line models exhibit...
OPEN ACCESS ARTICLE
Select this article
Research: APOBEC3A drives deaminase mutagenesis in human gastric epithelium
- Yohan An,
- Ji-Hyun Lee,
- Joonoh Lim,
- Jeonghwan Youk,
- Seongyeol Park,
- Ji-Hyung Park,
- Kijong Yi,
- Taewoo Kim,
- Chang Hyun Nam,
- Won Hee Lee,
- Soo A Oh,
- Yoo Jin Bae,
- Thomas M. Klompstra,
- Haeun Lee,
- Jinju Han,
- Junehwak Lee,
- Jung Woo Park,
- Jie-Hyun Kim,
- Hyunki Kim,
- Hugo Snippert,
- Bon-Kyoung Koo,
- and Young Seok Ju
Genome Res. October 2025 35: 2158-2172; Published in Advance August 26, 2025, doi:10.1101/gr.280338.124
...-associated mutationsIn cancer s, APOBEC-induced localized hypermutation events are frequently observed (Nik-Zainal et al. 2012a; The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium 2020). Across the mutations detected in our hGOiA3A and TP53KO-hGOiA3A lines, ∼5% of the 29,650 acquired base substitutions were...
OPEN ACCESS ARTICLE
Select this article
Research: Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors
- Mi Ni Huang,
- Willie Yu,
- Wei Wei Teoh,
- Maude Ardin,
- Apinya Jusakul,
- Alvin Wei Tian Ng,
- Arnoud Boot,
- Behnoush Abedi-Ardekani,
- Stephanie Villar,
- Swe Swe Myint,
- Rashidah Othman,
- Song Ling Poon,
- Adriana Heguy,
- Magali Olivier,
- Monica Hollstein,
- Patrick Tan,
- Bin Tean Teh,
- Kanaga Sabapathy,
- Jiri Zavadil,
- and Steven G. Rozen
Genome Res. September 2017 27: 1475-1486; Published in Advance July 24, 2017, doi:10.1101/gr.220038.116
...(International Agency for Research on Cancer) Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first whole- data on the mutational signatures of AFB1 exposure from a total of >40,000mutations in four experimental systems: two different human cell lines, in liver tumors...
OPEN ACCESS ARTICLE

For checked items

view abstracts
download to citation manager

Searching journal content for articles similar to Kan et al. 23 (9): 1422.

Search Results

Modify Results

This search

Preprint Server

Current Issue

In This Issue

Citation format:
Results / page:
Results order: