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INSIGHT/OUTLOOK: Sleepy Dogs Don't Lie: A Genetic Disorder Informative About Sleep
- Thomas S. Kilduff
Genome Res. April 1, 2001 11: 509-511; doi:10.1101/gr.184301
...that the latency between sleep onset and the first REM period is greatly reduced in narcoleptics, narcolepsy has been thought to be a disorder of REM sleep. The mode of inheritance of narcolepsy is complex: Although 1%–2% of the first-degree relatives of narcoleptic patients manifest the disorder (compared with 0...
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ARTICLE: Identification and Functional Analysis of Mutations in the Hypocretin (Orexin) Genes of Narcoleptic Canines
- Marcel Hungs,
- Jun Fan,
- Ling Lin,
- Xiaoyan Lin,
- Richard A. Maki,
- and Emmanuel Mignot
Genome Res. April 1, 2001 11: 531-539; Published in Advance March 13, 2001, doi:10.1101/gr.161001
...1Stanford Center for Narcolepsy, Stanford University Medical Center, Department of Psychiatry and Behavioral Sciences, Palo Alto, California 94304-5485, USA; 2Neurocrine Biosciences, San Diego, California 92121, USA Abstract Narcolepsy is a sleep disorder affecting animals and humans. Exon...
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PERSPECTIVE: The canine genome
- Elaine A. Ostrander and
- Robert K. Wayne
Genome Res. December 2005 15: 1706-1716; doi:10.1101/gr.3736605
...( Lin et al. 1999 ) in Doberman Pinschers with inherited narcolepsy has proven key to understanding the molecular mechanisms which regulate sleep ( Nishino et al. 2000 ; Thannickal et al. 2000 ). In humans, the disease is associated with a progressive loss of hypocretin-expressing neurons and is a non...
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LETTER: An ~140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival
- John C. Fyfe,
- Marilyn Menotti-Raymond,
- Victor A. David,
- Lars Brichta,
- Alejandro A. Schäffer,
- Richa Agarwala,
- William J. Murphy,
- William J. Wedemeyer,
- Brittany L. Gregory,
- Bethany G. Buzzell,
- Meghan C. Drummond,
- Brunhilde Wirth,
- and Stephen J. O'Brien
Genome Res. September 2006 16: 1084-1090; Published in Advance August 9, 2006, doi:10.1101/gr.5268806
...severity and SMN protein level in spinal muscular atrophy . Nat. Genet. 16 : 265 – 269 . ↵ Lin L. , Faraco J. , Li R. , Kadotani H. , Rogers W. , Lin X. , Qiu X. , de Jong P.J. , Nishino S. , Mignot E. ( 1999 ) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor...
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RESOURCE: Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes
- Matthew Breen,
- Sophie Jouquand,
- Corinne Renier,
- Cathryn S. Mellersh,
- Christophe Hitte,
- Nigel G. Holmes,
- Angélique Chéron,
- Nicola Suter,
- Françoise Vignaux,
- Anna E. Bristow,
- Catherine Priat,
- E. McCann,
- Catherine André,
- Sam Boundy,
- Paul Gitsham,
- Rachael Thomas,
- Wendy L. Bridge,
- Helen F. Spriggs,
- Ed J. Ryder,
- Alistair Curson,
- Jeff Sampson,
- Elaine A. Ostrander,
- Matthew M. Binns,
- and Francis Galibert
Genome Res. October 1, 2001 11: 1784-1795; doi:10.1101/gr.189401
...are evidenced by the localization of disease loci for canine renal cancer, narcolepsy, multiple forms of retinitis pigmentosa, hematologic disorders, and several metabolic diseases (e.g., Henthorn et al. 1994 ; Yuzbasiyan-Gurkan et al. 1997 ; Acland et al. 1998 ; Lingaas et al. 1998 ; Lin et al. 1999...
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Dog Special/Letters: Short interspersed elements (SINEs) are a major source of canine genomic diversity
- Wei Wang and
- Ewen F. Kirkness
Genome Res. December 2005 15: 1798-1808; doi:10.1101/gr.3765505
.... 2003 . The birth of an alternatively spliced exon: 3′ splice-site selection in Alu exons. Science 300 : 1288 -1291. ↵ Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S., and Mignot, E. 1999 . The sleep disorder canine narcolepsy is caused by a mutation...

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