Searching journal content for articles similar to Johnson et al. 14 (12): 2448.

Displaying results 1-10 of 15
For checked items
  1. .....org (Yoshihama et al. 2002; Perry 2005; Yamashita et al. 2008; Parry et al. 2010). The tunicate Ciona intestinalis, which is an invertebrate chordate, has recently emerged as a powerful model organism for biological research (Sasakura et al. 2012; Stolfi and Christiaen 2012). The draft sequence of C...
  2. ...-posterior cell polarity of notochord cells. Curr. Biol. 15 : 79 -85. ↵ Johnson, D.S., Davidson, B., Brown, C.D., Smith, W.C., and Sidow, A. 2004 . Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance. Genome Res. 14 : 2448 -2456...
  3. ...sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance. Genome Res. 14 : 2448 -2456. ↵ Kobayashi, M., Matsuda, M., Asakawa, S., Shimizu, N., Nagahama, Y., Satou, Y., and Satoh, N. 2002 . Construction of BAC libraries derived from the ascidian Ciona...
  4. ...Siepel et al. (2005) when the assembled sizes of the two Ciona species are considered (116.7 Mb and 157 Mb) ( Dehal et al. 2002 ; Vinson et al. 2005 ). One possible explanation is that in the Ciona intestinalis , relatively short noncoding regions, possibly regulatory elements, are under strong...
  5. ...haplotypes separately and then merging them to obtain a reference sequence. Our method was developed to assemble the genome of the sea squirt Ciona savignyi , which was sequenced to a depth of 12.7× from a single wild individual. By comparing finished clones of the two haplotypes we determined...
  6. ...conserved sequences with an interesting evolutionary history. They have remained practically unchanged in the 450 million years (Myr) since the divergence of fish and mammals (sequence identity of >74% over at least 100 bases) but do not appear to be conserved in urochordates, such as Ciona intestinalis...
  7. ...is strongly associated with evolutionary conservation in noncoding regulatory regions of Ciona ( Johnson et al. 2004 ). Another approach using aligned genomic sequences to predict CRMs is the computation of regulatory potential (RP), which captures context and pattern information in addition to conservation...
  8. ...of Ciona exhibit strong correspondence between evolutionary constraint and functional importance. Genome Res. 14 : 2448 -2456. ↵ Kellis, M., Patterson, N., Endrizzi, M., Birren, B., and Lander, E.S. 2003 . Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423...
  9. ...Close sequence comparisons are sufficient to identify human cis -regulatory elements Shyam Prabhakar 1 , 2 , 4 , Francis Poulin 1 , 3 , Malak Shoukry 1 , Veena Afzal 1 , Edward M. Rubin 1 , 2 , Olivier Couronne 1 , 2...
  10. ...Figs. S29, S30). Taken together, these results suggest that functionality is predictable by the sequence and decreases gradually by the strength of the TP53 binding site. Discussion The functional annotation of all regulatory elements in the noncoding part of the human is a key challenge in biology...
For checked items

Preprint Server