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Method: Prioritizing candidate disease genes by network-based boosting of genome-wide association data
- Insuk Lee,
- U. Martin Blom,
- Peggy I. Wang,
- Jung Eun Shim,
- and Edward M. Marcotte
Genome Res. July 2011 21: 1109-1121; Published in Advance May 2, 2011, doi:10.1101/gr.118992.110
...as well as direct network connections. Unlike mouse phenotypes, annotations for human disease genes are still extremely limited, spanning ;3000 gene-disease linkages in human versus nearly 100,000 in mouse (McGary et al. 2010). From annotations available at The Mendelian Inheritance in Man (OMIM) database...
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LETTER: Millions of Years of Evolution Preserved: A Comprehensive Catalog of the Processed Pseudogenes in the Human Genome
- Zhaolei Zhang,
- Paul M. Harrison,
- Yin Liu,
- and Mark Gerstein
Genome Res. December 2003 13: 2541-2558; doi:10.1101/gr.1429003
...processed pseudogenes for this important metabolic enzyme. Some pseudogenes also have medical implications, which are discussed below. Recent Decline in the Processed Pseudogene Biogenesis For each processed pseudogene, we calculated its evolutionary distance or sequence divergence from the present...

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