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Research: Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding–fasting response and the circadian clock
- François Mange,
- Viviane Praz,
- Eugenia Migliavacca,
- Ian M. Willis,
- Frédéric Schütz,
- Nouria Hernandez,
- and the CycliX Consortium
Genome Res. June 2017 27: 973-984; Published in Advance March 24, 2017, doi:10.1101/gr.217521.116
...may seem contradictory to previous results, which have shown liver TORC1 activation to be under circadian clock control; rhythmicity was maintained under constant darkness and under conditions of starvation (Jouffe et al. 2013), and translation and ribosome biogenesis was dependent on the circadian...
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Research: Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing
- Alaaddin Bulak Arpat,
- Angélica Liechti,
- Mara De Matos,
- René Dreos,
- Peggy Janich,
- and David Gatfield
Genome Res. July 2020 30: 985-999; Published in Advance July 23, 2020, doi:10.1101/gr.257741.119
...the pause site characteristics are, and whether they are functionally relevant is still poorly understood. Here, we have applied a modified ribosome profiling strategy to a mammalian organ, mouse liver, to directly reveal the sites where two ribosomes collide. The deep analysis of these ∼60-nt “disome...

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