Searching journal content for articles similar to Jager et al. 29 (7): 1067.

Displaying results 1-10 of 53
For checked items
  1. Research: Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repair
    • Kaitlynne A. Bohm,
    • Amelia J. Hodges,
    • Wioletta Czaja,
    • Kathiresan Selvam,
    • Michael J. Smerdon,
    • Peng Mao,
    • and John J. Wyrick
    Genome Res. June 2021 31: 1047-1059; Published in Advance May 17, 2021, doi:10.1101/gr.274373.120
    ...Cancer Center, Albuquerque, NM 87131, USA Corresponding author: jwyrick@wsu.eduAbstractNucleosomes are a significant barrier to the repair of UV damage because they impede damage recognition by nucleotide excision repair (NER). The RSC and SWI/SNF chromatin remodelers function in cells to promote DNA...
  2. Research: Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin
    • Shirong Yu,
    • Katie Evans,
    • Patrick van Eijk,
    • Mark Bennett,
    • Richard M. Webster,
    • Matthew Leadbitter,
    • Yumin Teng,
    • Raymond Waters,
    • Stephen P. Jackson,
    • and Simon H. Reed
    Genome Res. October 2016 26: 1376-1387; Published in Advance July 28, 2016, doi:10.1101/gr.209106.116
    ...Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin Shirong Yu 1 , 3 , 4 , Katie Evans 1 , 3 , Patrick van Eijk 1 , Mark Bennett 1 , Richard M. Webster 1 , Matthew...
    OPEN ACCESS ARTICLE
  3. Research: Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers
    • Bettina Meier,
    • Nadezda V. Volkova,
    • Ye Hong,
    • Pieta Schofield,
    • Peter J. Campbell,
    • Moritz Gerstung,
    • and Anton Gartner
    Genome Res. May 2018 28: 666-675; Published in Advance April 10, 2018, doi:10.1101/gr.226845.117
    ...to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the . DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different cancer types. Although it is possible to associate mutational signatures extracted from human cancers with possible mutational...
    OPEN ACCESS ARTICLE
  4. Research: Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity
    • Peng Mao,
    • Alexander J. Brown,
    • Ewa P. Malc,
    • Piotr A. Mieczkowski,
    • Michael J. Smerdon,
    • Steven A. Roberts,
    • and John J. Wyrick
    Genome Res. October 2017 27: 1674-1684; Published in Advance September 14, 2017, doi:10.1101/gr.225771.117
    ...function in NMP removal in a BER-deficient strain. In contrast, deletion of RAD16, which causes a specific defect in the global nucleotide excision repair (GG-NER) pathway and is highly sensitive to UV irradiation (Supplemental Fig. S12) but does not affect TC-NER, did not showelevatedMMS sensitivity...
  5. Research: In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
    • Arnoud Boot,
    • Mi Ni Huang,
    • Alvin W.T. Ng,
    • Szu-Chi Ho,
    • Jing Quan Lim,
    • Yoshiiku Kawakami,
    • Kazuaki Chayama,
    • Bin Tean Teh,
    • Hidewaki Nakagawa,
    • and Steven G. Rozen
    Genome Res. May 2018 28: 654-665; Published in Advance April 9, 2018, doi:10.1101/gr.230219.117
    ...-coupled nucleotide excision repair (TC-NER) of adducted bases in the transcribed (antisense) strands. Since cisplatin forms adducts on purines, we would expect reduced numbers of mutations when G and A are on the transcribed strand (corresponding to C and T on the sense strand). As expected, C > A, C > T, and T...
  6. Research: C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
    • Bettina Meier,
    • Susanna L. Cooke,
    • Joerg Weiss,
    • Aymeric P. Bailly,
    • Ludmil B. Alexandrov,
    • John Marshall,
    • Keiran Raine,
    • Mark Maddison,
    • Elizabeth Anderson,
    • Michael R. Stratton,
    • Anton Gartner,
    • and Peter J. Campbell
    Genome Res. October 2014 24: 1624-1636; Published in Advance July 16, 2014, doi:10.1101/gr.175547.114
    ...-induced liver cancers. Mutational burden increased with impaired nucleotide excision repair. Cisplatin and mechlorethamine, DNA crosslinking agents, caused dose- and genotype-dependent signatures among indels, substitutions, and rearrangements. Strikingly, both agents induced clustered rearrangements resembling...
    OPEN ACCESS ARTICLE
  7. Method: High resolution mapping of modified DNA nucleobases using excision repair enzymes
    • D. Suzi Bryan,
    • Monica Ransom,
    • Biniam Adane,
    • Kerri York,
    • and Jay R. Hesselberth
    Genome Res. September 2014 24: 1534-1542; Published in Advance July 11, 2014, doi:10.1101/gr.174052.114
    ...and base excision repair. Signatures of uracilmediated mutations are widespread among cancer subtypes, and 2014 Bryan et al. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4...
    OPEN ACCESS ARTICLE
  8. Method: DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution
    • Juniper J. Elacqua,
    • Navpreet Ranu,
    • Sarah E. DiIorio,
    • and Paul C. Blainey
    Genome Res. January 2021 31: 75-87; Published in Advance December 21, 2020, doi:10.1101/gr.265223.120
    ...mismatch repair at the site before base excision repair can replace the deaminated nucleotide (Komor et al. 2016; Gaudelli et al. 2017). Additionally, it has been shown that insertions can be made at nicks via homology directed repair with a designed donor DNA without nonhomologous end joining (NHEJ...
    OPEN ACCESS ARTICLE
  9. Research: Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer
    • Peng Mao,
    • Michael J. Smerdon,
    • Steven A. Roberts,
    • and John J. Wyrick
    Genome Res. January 2020 30: 12-21; Published in Advance December 23, 2019, doi:10.1101/gr.253146.119
    ...nucleotide excision repair (NER) of the nontranscribed strand (NTS) of genes in an asymmetric manner, with faster repair of UV damage occurring on the 5′ side of the nucleosomal DNA. Analysis of genomic repair data from UV-irradiated human cells indicates that NER activity along the NTS is also elevated...
  10. Research: Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors
    • Mi Ni Huang,
    • Willie Yu,
    • Wei Wei Teoh,
    • Maude Ardin,
    • Apinya Jusakul,
    • Alvin Wei Tian Ng,
    • Arnoud Boot,
    • Behnoush Abedi-Ardekani,
    • Stephanie Villar,
    • Swe Swe Myint,
    • Rashidah Othman,
    • Song Ling Poon,
    • Adriana Heguy,
    • Magali Olivier,
    • Monica Hollstein,
    • Patrick Tan,
    • Bin Tean Teh,
    • Kanaga Sabapathy,
    • Jiri Zavadil,
    • and Steven G. Rozen
    Genome Res. September 2017 27: 1475-1486; Published in Advance July 24, 2017, doi:10.1101/gr.220038.116
    ...they illuminate endogenous mutagenic processes and mechanisms of DNA damage and repair (Alexandrov and Stratton 2014; Helleday et al. 2014; Poon et al. 2014; Nik-Zainal et al. 2015; Hollstein et al. 2016). Despite the progress in computational analysis of mutational signatures, the experimental delineation...
    OPEN ACCESS ARTICLE
For checked items

Search Results

Next 10 » New Search

Modify Results

Citation format:
Results / page:
Results order:

This search

  • Alert me when new articles matching this search are published
  • Download all citations on this page to my citation manager

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research