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Research: Alternative splicing generates HER2 isoform diversity underlying antibody–drug conjugate resistance in breast cancer
- Gabriela D.A. Guardia,
- Carlos H. dos Anjos,
- Aline Rangel-Pozzo,
- Filipe F. dos Santos,
- Alexander Birbrair,
- Paula F. Asprino,
- Anamaria A. Camargo,
- and Pedro A.F. Galante
Genome Res. September 2025 35: 1942-1958; Published in Advance July 15, 2025, doi:10.1101/gr.280304.124
...with nine noncoding isoforms. Importantly, the annotation of HER2 isoforms remained unchanged from GENCODE V36 to GENCODE V47 (Kaur et al. 2024), which includes an expanded catalog of transcript annotations based on long-read RNA sequencing (RNA-seq) data. By using full-length mRNA transcripts (see Methods...
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Editorial: Revolutionizing genomics and medicine—one long molecule at a time
- Ana Conesa,
- Alexander Hoischen,
- and Fritz J. Sedlazeck
Genome Res. November 2024 34: ix-xi; doi:10.1101/gr.280179.124
..., Brannan KW, Zhou CJ, Underwood JG, Yeo GW. 2024. Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution. Genome Res (this issue) 34: 2012–2024. doi:10.1101/gr.279176.124 ↵Jha A, Bohaczuk SC, Mao Y, Ranchalis J, Mallory BJ, Min AT, Hamm MO, Swanson E, Dubocanin D...

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