Searching journal content for articles similar to Hurt et al. 23 (10): 1636.

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  1. Research: Endonucleolytic cleavage is the primary mechanism of decay elicited by C. elegans nonsense-mediated mRNA decay
    • Marcus J. Viscardi,
    • Enisha Sehgal,
    • and Joshua A. Arribere
    Genome Res. June 2025 35: 1337-1348; Published in Advance May 9, 2025, doi:10.1101/gr.280046.124
    ...truncated and dominantly acting proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via the nonsense-mediated mRNA decay (NMD) pathway. The precise reactions by which cells attack NMD-target mRNAs remain obscure, precluding a biochemical understanding of NMD and hampering...
  2. Research: A GC-rich sequence feature in the 3′ UTR directs UPF1-dependent mRNA decay in mammalian cells
    • Naoto Imamachi,
    • Kazi Abdus Salam,
    • Yutaka Suzuki,
    • and Nobuyoshi Akimitsu
    Genome Res. March 2017 27: 407-418; Published in Advance December 9, 2016, doi:10.1101/gr.206060.116
    .... 2008. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14: 2609–2617. ↵Hurt JA, Robertson AD, Burge CB. 2013. Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res 23: 1636–1650. ↵Imamachi N, Tani...
  3. Resource: Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring
    • Kyu-Hyeon Yeom,
    • Zhicheng Pan,
    • Chia-Ho Lin,
    • Han Young Lim,
    • Wen Xiao,
    • Yi Xing,
    • and Douglas L. Black
    Genome Res. June 2021 31: 1106-1119; Published in Advance April 8, 2021, doi:10.1101/gr.273904.120
    ...be sequestered in the nucleus until they are spliced or can undergo nuclear decay. Other intron-containing mRNAs are exported unspliced to the cytoplasm, where they can be translated or undergo nonsense-mediated mRNA decay (NMD). To categorize introns based on both their retention levels and location, FI values...
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