Searching journal content for articles similar to Huang et al. 34 (4): 515.

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  1. ...provides novel insights into the genomic regulatory landscape underlying antiviral 33 immunity in a farmed fish with a complex . 34 Introduction 35 The innate immune response to viral infection, which is mainly based on the type I interferon 36 (type I IFN) pathway is crucial to both disease progression...
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  2. ...Transposable elements contribute to the evolution of host shift–related genes in cactophilic Drosophila species Daniel Siqueira de Oliveira1,2,3, Anaïs Larue2, William Vilas Boas Nunes2, Francois Sabot4, Alejandra Bodelón5, María Pilar García Guerreiro5, Cristina Vieira2 and Claudia Marcia...
  3. ...proposed to exhibit a range of divergent features compared with histones in archaea and eukaryotes. However, no functional genomic studies of the properties of Bdellovibrionota chromatin have been carried out. In this work, we map the landscape of chromatin accessibility, active transcription, and three...
  4. ...Medical University (Naval Medical University), Shanghai 200433, China; 2Center for Translational Medicine, Second Military Medical University (Naval Medical University), Shanghai 200433, China; 3National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University...
  5. ...in cancer. In this study, we characterized the TE transcriptomic landscape using long-read RNA-seq and short-read RNA-seq in three cancer cell lines varying only in TP53 genetic status. To identify transcripts that use TEs as potential promoters, we developed a computational pipeline, TEProf3...
  6. ...metabolize compounds that are not digestible by the host, providing access to previously inaccessible nutrients (Yadav et al. 2018). Gut microbes also influence the host's immune system and impact host health through their metabolic byproducts (Sommer and Bäckhed 2013). The microbiome's composition, which...
  7. ....zhang@mssm.eduAbstractCancer is a complex disease with diverse molecular mechanisms that affect patient prognosis. Network-based approaches are effective in revealing a holistic picture of cancer prognosis and gene interactions. However, a comprehensive landscape of coexpression networks and prognostic gene modules across multiple cancer...
  8. ...including MER41_BT and Bov-A2 elements predicted to act as IFN-inducible enhancer elements. CRISPR knockout experiments in bovine cells established that critical immune factors including IFNAR2 and IL2RB are transcriptionally regulated by TE-derived enhancers. Finally, population genomic analysis of 38...
  9. ..., highlighting the importance of intercellular miRNA heterogeneity.In summary, although several studies have profiled miRNAs and their targets in single cells, there is a paucity of systematic and transcriptome-wide studies in individual mESCs. We here outline the landscape of miRNA and target expression...
  10. ...sequence can often be shared between two genes and in some occurrences, a gene is located completely within a different gene; these are known as host/nested gene pairs. In these instances, if both genes are transcribed, overlap can result in a transcriptional crosstalk where genes regulate each other...
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