Searching journal content for articles similar to Huang et al. 27 (9): 1475.

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  1. Research: In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
    • Arnoud Boot,
    • Mi Ni Huang,
    • Alvin W.T. Ng,
    • Szu-Chi Ho,
    • Jing Quan Lim,
    • Yoshiiku Kawakami,
    • Kazuaki Chayama,
    • Bin Tean Teh,
    • Hidewaki Nakagawa,
    • and Steven G. Rozen
    Genome Res. May 2018 28: 654-665; Published in Advance April 9, 2018, doi:10.1101/gr.230219.117
    ...a variety of known, suspected, or unknown causes (Alexandrov et al. 2013a,b; Forbes et al. 2017; cancer.sanger.ac.uk). Mutational signatures can serve as biomarkers for endogenous mutagenic processes and exogenous exposures that lead to the development of tumors.We hypothesize that cisplatin's mutational...
  2. Research: Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types
    • Arnoud Boot,
    • Alvin W.T. Ng,
    • Fui Teen Chong,
    • Szu-Chi Ho,
    • Willie Yu,
    • Daniel S.W. Tan,
    • N. Gopalakrishna Iyer,
    • and Steven G. Rozen
    Genome Res. June 2020 30: 803-813; Published in Advance July 6, 2020, doi:10.1101/gr.255620.119
    ...–2690. doi:10.1099/ijs.0.033613-0 ↵Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, et al. 2017. Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. Genome Res 27: 1475–1486. doi:10.1101/gr.220038.116 ↵Hurley LH, Rokem JS. 1983...
  3. Research: Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer
    • Myrthe Jager,
    • Francis Blokzijl,
    • Ewart Kuijk,
    • Johanna Bertl,
    • Maria Vougioukalaki,
    • Roel Janssen,
    • Nicolle Besselink,
    • Sander Boymans,
    • Joep de Ligt,
    • Jakob Skou Pedersen,
    • Jan Hoeijmakers,
    • Joris Pothof,
    • Ruben van Boxtel,
    • and Edwin Cuppen
    Genome Res. July 2019 29: 1067-1077; Published in Advance June 20, 2019, doi:10.1101/gr.246223.118
    .... Mutational characteristics of NER-deficiency may reveal important diagnostic opportunities, as tumors deficient in NER are more sensitive to certain treatments. Here, we analyzed the -wide somatic mutational profiles of adult stem cells (ASCs) from NER-deficient Ercc1−/Δ mice. Our results indicate that NER...
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  4. Research: Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans
    • Maria Zhivagui,
    • Alvin W.T. Ng,
    • Maude Ardin,
    • Mona I. Churchwell,
    • Manuraj Pandey,
    • Claire Renard,
    • Stephanie Villar,
    • Vincent Cahais,
    • Alexis Robitaille,
    • Liacine Bouaoun,
    • Adriana Heguy,
    • Kathryn Z. Guyton,
    • Martha R. Stampfer,
    • James McKay,
    • Monica Hollstein,
    • Magali Olivier,
    • Steven G. Rozen,
    • Frederick A. Beland,
    • Michael Korenjak,
    • and Jiri Zavadil
    Genome Res. April 2019 29: 521-531; Published in Advance March 7, 2019, doi:10.1101/gr.242453.118
    ...through the effects of its reactive metabolite glycidamide. We next show that the glycidamide mutational signature is found in a full one-third of approximately 1600 tumor s corresponding to 19 human tumor types from 14 organs. The highest enrichment of the glycidamide signature was observed...
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