Searching journal content for articles similar to Hu et al. 34 (10): 1582.

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  1. ...-down assay combined with quantitative mass spectrometry using methylated DNA probes for each DNA sequence context. All mC readers known to date preferentially bind to the methylated probes, along with a range of new mC-binding protein candidates. Functional characterization of these mC readers, focused...
  2. ....3%) attributed to somatically acquired 66 copy-number alterations (CNA) in the tumor DNA [PCAWG Transcriptome Core Group 2020]. 67 More recent studies have attempted to characterize ASE events independent of somatic 68 CNA by focusing on ASE of somatic mutations [Palou-Márquez et al. 2024; Black et al. 2025; 69...
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  3. ...24 0 to 8 hours) integrates over 250 paired transcriptome and proteome measurements. We 25 observe upregulation of known DNA repair proteins as well as a global dynamic response of 26 not yet characterized transcripts and proteins. Using artificial neural networks, we classify 27 different expression...
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  4. ...and apologize for any confusion this may have caused.doi: 10.1101/gr.280860.125 Published by Cold Spring Harbor Laboratory Press Corrigendum: Characterization of DNA methylation reader proteins in Arabidopsis thaliana Jonathan Cahn , James P.B. Lloyd , Ino D. Karemaker , Pascal W.T.C. Jansen , Jahnvi Pflueger...
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  5. ..., Pennsylvania 19104, USA Corresponding authors: montanoc@chop.edu, wtimp@jhu.eduAbstractIn this mini-review, we explore the advancements in -wide DNA methylation profiling, tracing the evolution from traditional methods such as methylation arrays and whole- bisulfite sequencing to the cutting-edge single...
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  6. ...genes with dosage sensitivity to the Y number are shown. Pearson's correlation coefficient (R), P-value, and FDR are indicated.The presence of an extra Y Chromosome results in subtle changes in DNA methylationTo understand the impact of an extra Y Chromosome on global DNA methylation, we performed...
  7. ....Transcriptional regulation in eukaryotes is profoundly influenced by chromatin status, integrating diverse cellular signals to control gene expression (Berger 2007). Chromatin dynamics are modulated by multiple mechanisms, including histone modifications, DNA methylation, and chromatin remodeling complexes (Shilatifard 2006...
  8. ...around 1, with low dispersion across the read length (Fig. 1C). As exceptions, we found DNA molecules with global anomalies in IPDr, whose baseline dispersed or deviated from 1 (Supplemental Fig. S1C,D), possibly due to a compromised DNA polymerase. We also found DNA molecules with local anomalies...
  9. ...approaches to seven well-characterized human cell lines—including HG002—for a comparative analysis of targeted and -wide methylation protocols. Their MethylSeq protocol involved using dual indexing primers to generate MethylSeq libraries with EZ DNA Methylation-Gold kit used for bisulfite conversion...
  10. ...half of HCC cases globally occur in China, where chronic hepatitis B virus (HBV) infection is the major etiological factor, accounting for over 60% of cases (Llovet et al. 2021; Bray et al. 2024; Chen et al. 2024a). Somatic DNA alterations are known as pivotal drivers of HCC tumorigenesis...
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