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  1. ...with the ribosomal DNA (rDNA) array, which occurs in many copies on the acrocentric Chromosomes 13, 14, 15, 21, and 22 (Agrawal and Ganley 2018; Nurk et al. 2022; Chao et al. 2023). Given this overlap with rDNA, we suspect that the source genes are not protein-coding genes, and manual curation would be required...
  2. ...Repetitive sequence variation and dynamics in the ribosomal DNA array of Saccharomyces cerevisiae as revealed by whole-genome resequencing Stephen A. James 1 , 4 , Michael J.T. O'Kelly 2 , 4 5 , David M. Carter 3 , 6 , Robert P. Davey 1...
  3. ...examples like histone genes (Maxson et al. 1983), rDNA arrays (Hall et al. 2022), and immunoglobulin genes (Watson and Breden 2012). Tandem repeats are prone to rapid copy number changes mediated through mechanisms such as unequal crossing over, replication slippage, gene conversion, and intrachromatid...
  4. ...contigs, except for contigs 16 and 17, which show enrichment only at one end (Supplemental Fig. S2). These two contigs carry 45S rDNA loci at the ends lacking telomeric repeats (see Results section “45S rDNA genes are organized as a single tandem array with only one diverging locus dispersed throughout...
  5. ...-color hybridization on combed human DNA. The red probe is the 5′ EcoRI fragment B detected with Texas Red. The green probe is the 3′ fragment A detected with FITC. The image displays 10 canonical rDNA units in tandem, each composed of a dual fluorescent signal and the adjacent nonhybridizing spacer segments. ( C...
  6. ...blue. The positions of the PZ region (green), pmp clusters (purple; numbered 1–4), tmh cluster (blue), and biotin biosynthetic operon (yellow) are shown as colored boxes on the DNA lines. All the s have been oriented at the origin of replication to start at the hemB gene. More detailed analysis...
  7. ...the homogeneously: While some genes are frequently found methylated in cancer, others are never or rarely targeted by such modification. The causes of selective predisposition to methylation are unknown, and twomain explanations have been proposed: (1) DNA methylation happens randomly, and cells with silencing...
  8. ...the kinetochore(s) and attaches to spindle microtubules (Fig. 1A–D; Malik and Henikoff 2009; Melters et al. 2013; Naish et al. 2021). In monocentric plant s, the DNA sequences underlying the centromeres are frequently composed of megabase-scale tandem repeat arrays (Malik and Henikoff 2009; Melters et al. 2013...
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  9. ...different classes of repetitive elements that are categorized based largely on their copy number and their mode of propagation ( Gardiner 1996 ; Vogt 1990 ). Two broad classes of repeats are generally recognized: interspersed and tandem repeat elements ( Brown 1999 ). Tandemly repeated DNA...
  10. ...: Evidence for localized homogeneous sequence domains within arrays of α-satellite DNA. J. Mol. Biol. 216 : 3 – 16 . ↵ Wevrick R. , Willard H.F. ( 1989 ) Long-range organization of tandem arrays of α satellite DNA at the centromeres of human chromosomes: High-frequency array-length polymorphism and meiotic...
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