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LETTER: Variants in the GH-IGF axis confer susceptibilityto lung cancer
- Matthew F. Rudd,
- Emily L. Webb,
- Athena Matakidou,
- Gabrielle S. Sellick,
- Richard D. Williams,
- Helen Bridle,
- Tim Eisen,
- Richard S. Houlston,
- and the GELCAPS Consortium
Genome Res. June 2006 16: 693-701; doi:10.1101/gr.5120106
.... Natl. Acad. Sci. 98 : 13784 – 13789 . ↵ Hoh J. , Wille A. , Ott J. ( 2001 ) Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res. 11 : 2115 – 2119 . ↵ Howlett N.G. , Taniguchi T. , Olson S. , Cox B. , Waisfisz Q. , De Die-Smulders C. , Persky N. , Grompe M...
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Research: Copy number variation underlies complex phenotypes in domestic dog breeds and other canids
- Aitor Serres-Armero,
- Brian W. Davis,
- Inna S. Povolotskaya,
- Carlos Morcillo-Suarez,
- Jocelyn Plassais,
- David Juan,
- Elaine A. Ostrander,
- and Tomas Marques-Bonet
Genome Res. May 2021 31: 762-774; Published in Advance April 16, 2021, doi:10.1101/gr.266049.120
...canids to explore the association between CNVs and phenotypes, showing clear and reproducible differences between established breed clades. GWASs with absolute CN as the testable variable are not common in the literature, especially outside of the field of human genetics (The Wellcome Trust Case Control...
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Research: Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiome
- Daniela S. Aliaga Goltsman,
- Christine L. Sun,
- Diana M. Proctor,
- Daniel B. DiGiulio,
- Anna Robaczewska,
- Brian C. Thomas,
- Gary M. Shaw,
- David K. Stevenson,
- Susan P. Holmes,
- Jillian F. Banfield,
- and David A. Relman
Genome Res. October 2018 28: 1467-1480; Published in Advance September 19, 2018, doi:10.1101/gr.236000.118
...subjects than to the co-occurring within the same subject (Fig. 4C). When using the ATCC 14019 type strain as reference, the total number of SNPs across the s did not correlate with the group phylogeny. In other words, a divergent clade does not necessarily harbor more SNPs than strains within Clade 1...
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Resource: Mitochondrial DNA variation across 56,434 individuals in gnomAD
- Kristen M. Laricchia,
- Nicole J. Lake,
- Nicholas A. Watts,
- Megan Shand,
- Andrea Haessly,
- Laura Gauthier,
- David Benjamin,
- Eric Banks,
- Jose Soto,
- Kiran Garimella,
- James Emery,
- Genome Aggregation Database Consortium,
- Heidi L. Rehm,
- Daniel G. MacArthur,
- Grace Tiao,
- Monkol Lek,
- Vamsi K. Mootha,
- and Sarah E. Calvo
Genome Res. March 2022 32: 569-582; Published in Advance January 24, 2022, doi:10.1101/gr.276013.121
...% of samples are not annotated with case/control status, including some disease studies and population-based observational cohort studies, with the following breakdown by study disease domain: 38% cardiac; 16% pulmonary; 2% neurological; and <1% other/unknown.Mitochondrial variant calling pipeline in single...
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Research: Genome-wide analysis of differential RNA editing in epilepsy
- Prashant Kumar Srivastava,
- Marta Bagnati,
- Andree Delahaye-Duriez,
- Jeong-Hun Ko,
- Maxime Rotival,
- Sarah R. Langley,
- Kirill Shkura,
- Manuela Mazzuferi,
- Bénédicte Danis,
- Jonathan van Eyll,
- Patrik Foerch,
- Jacques Behmoaras,
- Rafal M. Kaminski,
- Enrico Petretto,
- and Michael R. Johnson
Genome Res. March 2017 27: 440-450; doi:10.1101/gr.210740.116
...also reflect several of the behavioral and cognitive disturbances associated with TLE in humans (Groticke et al. 2007).ResultsStudy designThe study design used for the -wide differential RE association analysis of epilepsy was a case control analysis using a mouse model of acquired symptomatic TLE (Fig...
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