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Research: Sir3 mediates long-range chromosome interactions in budding yeast
- Myriam Ruault,
- Vittore F. Scolari,
- Luciana Lazar-Stefanita,
- Antoine Hocher,
- Isabelle Loïodice,
- Romain Koszul,
- and Angela Taddei
Genome Res. March 2021 31: 411-425; Published in Advance February 12, 2021, doi:10.1101/gr.267872.120
...is limited by the titration of SIR proteins, especially Sir3, and by H3K79me3, which prevents Sir3 binding in euchromatic regions. Indeed, overexpression of Sir3 leads to the formation of extended silent domains (ESD) covering subtelomeric regions and delimited by transition zones where H3K79me3 levels...
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Research: Transcriptional variation in the malaria parasite Plasmodium falciparum
- Núria Rovira-Graells,
- Archna P. Gupta,
- Evarist Planet,
- Valerie M. Crowley,
- Sachel Mok,
- Lluís Ribas de Pouplana,
- Peter R. Preiser,
- Zbynek Bozdech,
- and Alfred Cortés
Genome Res. May 2012 22: 925-938; Published in Advance March 13, 2012, doi:10.1101/gr.129692.111
...showed opposite expression patterns in some parasite lines (Fig. 6E). The general lack of coordinated expression in clusters of neighboring genes that can be repressed by formation of heterochromatin indicates that subtelomeric regions are organized into small chromatin domains, possibly delimitated...

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