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  1. ...Annotation Transfer Between Genomes: Protein–Protein Interologs and Protein–DNA Regulogs Haiyuan Yu 1 , Nicholas M. Luscombe 1 , Hao Xin Lu 1 , Xiaowei Zhu 1 , Yu Xia 1 , Jing-Dong J. Han 2 , Nicolas Bertin 2...
  2. ....I. 2002 . From knowledge-based potentials to combinatorial lead design in silico. Acc. Chem. Res. 35 : 261 -269. ↵ Hegyi, H. and Gerstein, M. 2001 . Annotation transfer for genomics: Measuring functional divergence in multi-domain proteins. Genome Res. 11 : 1632 -1640. ↵ Holm, L. and Sander, C. 1993...
  3. ...to these characterized motifs/domains, suggestion for a functional annotation comes from a homology to a previously functionally annotated sequence. However, transfer of function via an identified homology is problematic and the extent of the difficulty has been recently quantified (e.g., Devos and Valencia 2000...
  4. ...15 : 228 – 233 . ↵ Gene Ontology Consortium ( 2001 ) Creating the gene ontology resource: Design and implementation. Genome Res. 11 : 1425 – 1433 . ↵ Hegyi H. , Gerstein M. ( 2001 ) Annotation transfer for genomics: Measuring functional divergence in multi-domain proteins. Genome Res. 11 : 1632...
  5. ...-Delbrück-Centrum for Molecular Medicine, 13122 Berlin-Buch, Germany Abstract In the course of evolution, genomes are shaped by processes like gene loss, gene duplication, horizontal gene transfer, and gene genesis (the de novo origin of genes). Here we reconstruct the gene content of ancestral Archaea...
  6. ...or fission. New genes for an existing function could be acquired by horizontal transfer or functional displacement of one gene by another within a . In addition, many new genes have arisen by duplication and divergence to produce new enzymatic functions and pathways. Until now, investigations...
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