Searching journal content for articles similar to Hausser et al. 19 (11): 2009.

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  1. Resource: Small RNA expression and miRNA modification dynamics in human oocytes and early embryos
    • Pauliina Paloviita,
    • Christel Hydén-Granskog,
    • Dawit A. Yohannes,
    • Priit Paluoja,
    • Juha Kere,
    • Juha S. Tapanainen,
    • Kaarel Krjutškov,
    • Timo Tuuri,
    • Urmo Võsa,
    • and Sanna Vuoristo
    Genome Res. August 2021 31: 1474-1485; doi:10.1101/gr.268193.120
    ..., suggesting differences in the accumulation of maternal miRNAs compared to that of mRNAs, which are highly abundant and stored in ribonucleoprotein complexes during oogenesis (Nakamura et al. 2001; Richter and Lasko 2011; Christou-Kent et al. 2020). Indeed, the low expression levels of maternal miRNAs...
  2. Research: Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation
    • Jean Hausser,
    • Afzal Pasha Syed,
    • Biter Bilen,
    • and Mihaela Zavolan
    Genome Res. April 2013 23: 604-615; Published in Advance January 18, 2013, doi:10.1101/gr.139758.112
    .... Interestingly, overexpression ofmost of these CDS/39UTR–cotargeting miRNAs has been linked with tumorigenesis (Voorhoeve Figure 1. (A) CDS- and 39 UTR-located miRNA binding sites that induce mRNA degradation or are isolated in EIF2C2 CLIP experiments are under stronger selection pressure compared with mi...
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  3. Research: A comprehensive survey of 3′ animal miRNA modification events and a possible role for 3′ adenylation in modulating miRNA targeting effectiveness
    • A. Maxwell Burroughs,
    • Yoshinari Ando,
    • Michiel J.L. de Hoon,
    • Yasuhiro Tomaru,
    • Takahiro Nishibu,
    • Ryo Ukekawa,
    • Taku Funakoshi,
    • Tsutomu Kurokawa,
    • Harukazu Suzuki,
    • Yoshihide Hayashizaki,
    • and Carsten O. Daub
    Genome Res. October 2010 20: 1398-1410; Published in Advance August 18, 2010, doi:10.1101/gr.106054.110
    ...effectiveness of miRNA targeting of mRNA transcripts while deep-sequencing of RNA bound to immunoprecipitated Argonaute (AGO) subfamily proteins EIF2C1–EIF2C3 revealed substantial reduction of adenine addition in miRNA associated with EIF2C2 and EIF2C3. Our findings show 3′ addition events are widespread...
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  4. Research: Signatures of RNA binding proteins globally coupled to effective microRNA target sites
    • Anders Jacobsen,
    • Jiayu Wen,
    • Debora S. Marks,
    • and Anders Krogh
    Genome Res. August 2010 20: 1010-1019; Published in Advance May 27, 2010, doi:10.1101/gr.103259.109
    ...as EIF2C1–EIF2C4) to directly sequence mRNA regions bound endogenously by AGO and plausibly under miRNA regulation. We first investigated enrichment of all 7-mer words in the corresponding full-length sequence of 39 UTRs bound by AGO (see Methods). The words most significantly enriched in bound relative...
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  5. Letter: Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis
    • Javier Armisen,
    • Michael J. Gilchrist,
    • Anna Wilczynska,
    • Nancy Standart,
    • and Eric A. Miska
    Genome Res. October 2009 19: 1766-1775; Published in Advance July 23, 2009, doi:10.1101/gr.093054.109
    ...superfamily of RNA-binding proteins (Cerutti et al. 2000). miRNAs are thought to inhibit efficient translation of target mRNAs or to control mRNA decay. Another class of small RNAs, 21–24 nucleotides (nt) endogenous siRNAs, was first discovered in plants in response to viral infection (Hamilton and Baulcombe...
  6. Platypus Special/Letter: Conservation of small RNA pathways in platypus
    • Elizabeth P. Murchison,
    • Pouya Kheradpour,
    • Ravi Sachidanandam,
    • Carly Smith,
    • Emily Hodges,
    • Zhenyu Xuan,
    • Manolis Kellis,
    • Frank Grützner,
    • Alexander Stark,
    • and Gregory J. Hannon
    Genome Res. June 2008 18: 995-1004; Published in Advance May 7, 2008, doi:10.1101/gr.073056.107
    ...–24 nt in length, to regulate genes post-transcriptionally ( Bartel 2004 ). miRNA duplexes are liberated from -encoded hairpins by successive processing by RNase III enzymes RNASEN (also known as Drosha) and DICER1 ( Bartel 2004 ). Incorporation into complexes containing members of the EIF2C (also known...
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