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  1. ...AT content for efficient mRNA editing (Rosenberg et al. 2011). In addition, the mRNA levels of several Apobec family genes, i.e., the key enzymes for C-to-U RNA editing, were differentially expressed between epileptic and control mice hippocampus, with increased expression in the epileptic hippocampus...
  2. ...of pseudouridine within in vivo systems have drawn mixed conclusions, including increasing (Schwartz et al. 2014; Dai et al. 2023), decreasing (Nakamoto et al. 2017), and having no effect on mRNA stability (Zhang et al. 2023).Genome-wide identification of RNA modificationsA-to-I and C-to-U RNA editing events can...
  3. ...variants. In contrast, other resources as well as genome-wide association studies (GWAS) in humans and other species reveal genetic architectures dominated with a relatively modest number of QTLs that have small individual and combined phenotypic effects. These contrasting architectures are the result...
  4. ...– 15 . ↵ Anant S. , Davidson N.O. ( 2000 ) An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: Binding of Apobec-1 to this motif in the 3′ untranslated region of c- myc increases mRNA stability. Mol. Cell. Biol. 20...
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