Searching journal content for articles similar to Harrill et al. 19 (9): 1507.

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Research: Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance
- Yang Xi,
- Jingjing Qi,
- Zhao Yang,
- Yutian Zeng,
- Huicong Zhang,
- Qiuyu Tao,
- Mengru Xu,
- Anqi Huang,
- Shenqiang Hu,
- Chunchun Han,
- Lili Bai,
- Jiwei Hu,
- Jiwen Wang,
- Liang Li,
- Lingzhao Fang,
- and Hehe Liu
Genome Res. October 2025 35: 2211-2225; Published in Advance September 10, 2025, doi:10.1101/gr.280345.124
...-tissue regulation of reproduction.With the development of high-throughput sequencing and the large-scale application of -wide association studies (GWASs), a substantial number of genomic variants that are associated with complex traits have been identified in humans and farmed animals (Abdellaoui et al. 2023; Tan...
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Research: Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits
- Kevin W. Currin,
- Hannah J. Perrin,
- Gautam K. Pandey,
- Abdalla A. Alkhawaja,
- Swarooparani Vadlamudi,
- Annie E. Musser,
- Amy S. Etheridge,
- K. Alaine Broadaway,
- Jonathan D. Rosen,
- Arushi Varshney,
- Amarjit S. Chaudhry,
- Paul J. Gallins,
- Fred A. Wright,
- Yi-hui Zhou,
- Stephen C.J. Parker,
- Laura M. Raffield,
- Erin G. Schuetz,
- Federico Innocenti,
- and Karen L. Mohlke
Genome Res. July 2025 35: 1485-1502; Published in Advance May 20, 2025, doi:10.1101/gr.279741.124
...these coordinately regulated element sets are formed, and identifying driver elements will help fine-map causal elements and variants at colocalized GWAS loci (van Mierlo et al. 2023).The liver influences many human traits and diseases through its role in protein synthesis, lipid and glucose metabolism...
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Review: Recent advances in methods to characterize archaic introgression in modern humans
- David Peede,
- Mayra M. Bañuelos,
- Jazeps Medina Tretmanis,
- Miriam Miyagi,
- and Emilia Huerta-Sánchez
Genome Res. February 2026 36: 239-256; Published in Advance January 16, 2026, doi:10.1101/gr.278993.124
...DNA suggested minimal to no Neanderthal contribution to the genetic diversity of modern human populations (Krings et al. 1997, 1999; Caramelli et al. 2003; Currat and Excoffier 2004; Serre et al. 2004). However, in 2010, the publication of the draft Neanderthal revealed that non-African populations...
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Research: Widespread natural selection on metabolite levels in humans
- Yanina Timasheva,
- Kaido Lepik,
- Orsolya Liska,
- Balázs Papp,
- and Zoltán Kutalik
Genome Res. August 2024 34: 1121-1129; Published in Advance August 16, 2024, doi:10.1101/gr.278756.123
...in the recent evolutionary past of humans. First, we found three metabolites (citrulline, lysoPC a C20:4, PC ae C40:5) with nominally significant positive . Second, we examined whether some large-effect genetic variants may have violated the LDAK model assumptions to yield positive selection coefficient...
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Method: k-mer cross-species profiling reveals taxon-specific TE expansions accompanied by KZFP co-option and functional impacts in ruminants
- Pengju Zhao,
- Jiayi He,
- Chen Peng,
- Yuelang Zhang,
- Chong Wang,
- Dongyou Yu,
- Lingzhao Fang,
- and Zhengguang Wang
Genome Res. March 23, 2026 gr.281289.125; Published in Advance March 23, 2026, doi:10.1101/gr.281289.125
...cattle at the breed level (Fig. 6C). Analysis of 2,262 samples across 11 cattle breeds 333 revealed 37,611 structural variants (PanCattle SV project, 334 https://doi.org/10.6084/m9.figshare.28021577), with 59.34% attributable to TEs and 951 SVs 335 specifically associated with Bovinae-specific TE...
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Research: Convergent relaxation of molecular constraint in herbivores reveals the changing role of liver and kidney functions across mammalian diets
- Matthew D. Pollard,
- Wynn K. Meyer,
- and Emily E. Puckett
Genome Res. December 2024 34: 2176-2189; Published in Advance November 22, 2024, doi:10.1101/gr.278930.124
...is most strongly expressed in the liver, kidneys, pancreas, or small intestine in humans (Fig. 2B; The GTEx Consortium 2015). We performed a gene set enrichment analysis to determine if there was a statistically significant association between the change in carnivory score and the rate of evolution...
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Research: A genome-wide survey reveals a diverse array of enhancers coordinates the Drosophila innate immune response
- Lianne B Cohen,
- Tamara Hadzic,
- Caitlin Sauer,
- Julia R Gibbs,
- and Zeba Wunderlich
Genome Res. April 15, 2026 gr.281432.125; Published in Advance April 15, 2026, doi:10.1101/gr.281432.125
...A -wide survey reveals a diverse array of enhancers coordinates the Drosophila 1 innate immune response 2 3 Lianne B. Cohen1, 2, Tamara Hadzic2, 3, Caitlin Sauer1, 2, Julia R. Gibbs1, 2, Zeba Wunderlich1, 2, 3, 4 4* 5 1. Department of Biology, Boston University, Boston, MA 02215, USA 6 2...
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Research: Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma
- Meilong Shi,
- Chuanqi Teng,
- Shan Zhang,
- Xiaobo He,
- Lingyun Xu,
- Fengxian Han,
- Rongqi Wen,
- Ganjun Yu,
- Jingwen Liu,
- Yang Feng,
- Yanfeng Wu,
- Yan Ren,
- Gang Jin,
- and Jing Li
Genome Res. February 2026 36: 275-290; Published in Advance January 8, 2026, doi:10.1101/gr.280528.125
...function and prognostic value. Notably, LTR7-PLAAT4, present in 29% of tumors, encodes a protein variant transcriptionally regulated by FOXM1 binding to the LTR7 promoter. LTR7-PLAAT4 isoform 2 is associated with increased cholesterol ester accumulation and lipid droplet formation mediated through BSCL2...
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Letter: An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity
- Hong-Hsing Liu,
- Peng Lu,
- Yingying Guo,
- Erin Farrell,
- Xun Zhang,
- Ming Zheng,
- Betty Bosano,
- Zhaomei Zhang,
- John Allard,
- Guochun Liao,
- Siyu Fu,
- Jinzhi Chen,
- Kimberly Dolim,
- Ayako Kuroda,
- Jonathan Usuka,
- Janet Cheng,
- William Tao,
- Kevin Welch,
- Yanzhou Liu,
- Joseph Pease,
- Steve A. de Keczer,
- Mohammad Masjedizadeh,
- Jing-Shan Hu,
- Paul Weller,
- Tim Garrow,
- and Gary Peltz
Genome Res. January 2010 20: 28-35; Published in Advance November 18, 2009, doi:10.1101/gr.097212.109
...-guided resequencing reveals that variants in CD44 contribute to acetaminopheninduced liver injury in humans. Genome Res 19: 1507–1515. Hogaboam CM, Bone-Larson CL, Steinhauser ML, Matsukawa A, Gosling J, Boring L, Charo IF, Simpson KJ, Lukacs NW, Kunkel SL. 2000. Exaggerated hepatic injury due to acetaminophen...
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Research: Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain
- James L. Shepherdson,
- David M. Granas,
- Jie Li,
- Zara Shariff,
- Stephen P. Plassmeyer,
- Alex S. Holehouse,
- Michael A. White,
- and Barak A. Cohen
Genome Res. October 2024 34: 1540-1552; Published in Advance September 25, 2024, doi:10.1101/gr.279415.124
..., Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA Corresponding author: cohen@wustl.eduAbstractThe transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause...
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