Searching journal content for articles similar to Han et al. 30 (8): 1097.

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  1. ...and Asian aboriginal Tibetan pigs. Using the F1 hybrid progeny, we then examine how allelic differences in 3D chromatin architecture broadly affect gene expression, and eventually phenotype, at multiple levels.ResultsConstruction of high-resolution diploid Hi-C contact mapsTo generate chromosome...
  2. ....2), they will be of great importance in exploring the genetic mechanisms underlying high-altitude genetic adaptation. Moreover, understanding the molecular basis of heterosis and phenotypic variation requires knowledge of diploid alleles (Sun et al. 2020). The high-resolution species-specific haploids of the F1-hybrid can...
  3. ...by running HipSTR on all single cells simultaneously using default values. HipSTR allelotypes were filtered to require a minimum 0.7 posterior probability of the genotype call. The resulting microsatellite allelotype consisted of a list of diploid microsatellite subunit counts for each single cell...
  4. ...Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China; 3State Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy...
  5. ..., despite their diploid composition (Barton et al. 1985). This work demonstrated the existence of functional differences between the two parental s and, in fact, highlighted the necessity of both a maternal and a paternal for proper mammalian development. Genetic studies in mouse embryos with uniparental...
  6. ...are in proximity for cross-linking and ligation, strongly scales negatively with the genomic distance between two regions, meaning that, on average, regions interact less the more intervening chromatin is between them (Lieberman-Aiden et al. 2009).CREs controlling developmentally regulated genes are typically...
  7. ...profile; (E) a representative diploid tumor profile; and (F) a representative tetraploid tumor profile. (G) Hierarchical clustering of this region by combining data from both the BAG method and 96-well WGA method.The method works on nuclei isolated from frozen tumor biopsies, and we illustrate this using...
  8. ...% of the nonrepetitive mouse , respectively. For comparison, LADs comprise ∼40% of the mouse (Guelen et al. 2008; Peric-Hupkes et al. 2010), and NADs in human diploid IMR-90 fibroblasts cover 38% of the (Dillinger et al. 2017). Also, XL and nonXL murine NADs had similar median lengths (Fig. 2D), comparable to MEF (534...
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