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  1. ...subfamily found in cyprinid fish, which is characterized by a conserved sequence we dubbed the fish N-terminal zinc finger–associated (FiNZ) domain. Zebrafish possess approximately 700 FiNZ-ZNFs, many of which are evolving adaptively under positive selection. Like mammalian KZNFs, most zebrafish Fi...
  2. ...(above) are shown. The TE subfamilies are colored according to their families. Primary targets for each KZFP are highlighted in red. (B) Zinc fingerprints of ZFP69 and ZFP69B. The DNA-contacting amino acids for zinc finger (ZF) are shown; differences are highlighted in red. (C) DNA binding motifs of ZFP...
  3. .... For brain development, primate-specific KRAB zinc-finger proteins (KZNFs) are specifically up-regulated in the mid-fetal stage, which may have contributed to the evolution of this critical stage. Altogether, hundreds of PSGs are either recruited to processes under strong selection pressure or to processes...
  4. .... , Baggott D.M. , Gordon L. , Stubbs L. , 2006 Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Genome Res. (this issue). ↵ Hoffmann A. , Ciani E. , Boeckardt J. , Holsboer F. , Journot L. , Spengler D. ( 2003 ) Transcriptional activities of the zinc finger...
  5. ...) account for more than 50% of the human and many have been co-opted throughout evolution to provide regulatory functions for gene expression networks. Several lines of evidence suggest that these networks are fine-tuned by the largest family of TE controllers, the KRAB-containing zinc finger proteins...
  6. ...and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Genome Res 16: 584– 594. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57–70. Hannenhalli S. 2008. Eukaryotic transcription factor binding sites–modeling and integrative search methods. Bioinformatics 24: 1325...
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