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Research: Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin
- Hossein Salari,
- Marco Di Stefano,
- and Daniel Jost
Genome Res. January 2022 32: 28-43; Published in Advance December 28, 2021, doi:10.1101/gr.275827.121
...2019). Over the last decade, high-throughput chromosome conformation capture (Hi-C) experiments have provided valuable information about how s organize by measuring the contact frequencies between all pairs of chromatin loci (Lieberman-Aiden et al. 2009). Analyses of Hi-C contact maps in various...
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Research: Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
- Sergey V. Ulianov,
- Ekaterina E. Khrameeva,
- Alexey A. Gavrilov,
- Ilya M. Flyamer,
- Pavel Kos,
- Elena A. Mikhaleva,
- Aleksey A. Penin,
- Maria D. Logacheva,
- Maxim V. Imakaev,
- Alexander Chertovich,
- Mikhail S. Gelfand,
- Yuri Y. Shevelyov,
- and Sergey V. Razin
Genome Res. January 2016 26: 70-84; Published in Advance October 30, 2015, doi:10.1101/gr.196006.115
...in Drosophila cells of different origin and developmental stages. Active chromatin marks and transcription interfere with chromatin fiber packaging into TADs Visual inspection of heat maps revealed that TADs in Drosophila cultured cells are often hierarchical (Fig. 1A), similar to TADs in Drosophila embryos...

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