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Research: Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
- Huriya Beyan,
- Thomas A. Down,
- Sreeram V. Ramagopalan,
- Kristina Uvebrant,
- Anita Nilsson,
- Michelle L. Holland,
- Carolina Gemma,
- Gavin Giovannoni,
- Bernhard O. Boehm,
- George C. Ebers,
- Åke Lernmark,
- Corrado M. Cilio,
- R. David Leslie,
- and Vardhman K. Rakyan
Genome Res. November 2012 22: 2138-2145; Published in Advance August 23, 2012, doi:10.1101/gr.134304.111
..., including promoters and CGIs, but also intergenic regions (Table 2). Interestingly, a few DMRs were located within genes associated with human diseases, e.g., FZD1 expression is down-regulated in ulcerative colitis (Hughes et al. 2011) andNFIAhas been associatedwith celiac disease (Dubois et al. 2010...
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Research: Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
- Luciano Pirola,
- Aneta Balcerczyk,
- Richard W. Tothill,
- Izhak Haviv,
- Antony Kaspi,
- Sebastian Lunke,
- Mark Ziemann,
- Tom Karagiannis,
- Stephen Tonna,
- Adam Kowalczyk,
- Bryan Beresford-Smith,
- Geoff Macintyre,
- Ma Kelong,
- Zhang Hongyu,
- Jingde Zhu,
- and Assam El-Osta
Genome Res. October 2011 21: 1601-1615; Published in Advance September 2, 2011, doi:10.1101/gr.116095.110
...changes. Mapping vascular epigenetic signatures Genome Research 1609 www..org Figure 7. Genome-wide changes conferred by hyperglycemia in the human vascular cell. (A) Human ideogram illustrating the correlation between histone acetylation and the methylome mediated by hyperglycemia. ChIP-seq tracks...

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