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Research: Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase
- Boning Chen,
- Heather K. MacAlpine,
- Alexander J. Hartemink,
- and David M. MacAlpine
Genome Res. December 2023 33: 2108-2118; Published in Advance December 11, 2023, doi:10.1101/gr.278273.123
...histone traffic and nucleosome dynamics. Annu Rev Biochem 83: 487–517. doi:10.1146/annurev-biochem-060713-035536 ↵Gutiérrez MP, MacAlpine HK, MacAlpine DM. 2019. Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork. Genome...
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Research: Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication
- Vinay Tripuraneni,
- Gonen Memisoglu,
- Heather K. MacAlpine,
- Trung Q. Tran,
- Wei Zhu,
- Alexander J. Hartemink,
- James E. Haber,
- and David M. MacAlpine
Genome Res. May 2021 31: 775-788; Published in Advance April 2, 2021, doi:10.1101/gr.271155.120
...in chromatin occupancy, we generated -wide chromatin occupancy profiles (GCOPs) (Henikoff et al. 2011; Belsky et al. 2015; Gutiérrez et al. 2019) by coupling paired-end sequencing with limited MNase digestion to reveal the factor-agnostic location of both nucleosomes and smaller DNA-binding factors. DNA...

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