Searching journal content for articles similar to Grimmond et al. 6 (2): 124.

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  1. Research: Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations
    • Anu Toropainen,
    • Lindsey K. Stolze,
    • Tiit Örd,
    • Michael B. Whalen,
    • Paula Martí Torrell,
    • Verena M. Link,
    • Minna U. Kaikkonen,
    • and Casey E. Romanoski
    Genome Res. March 2022 32: 409-424; Published in Advance February 22, 2022, doi:10.1101/gr.276064.121
    ...characterized in smooth muscle cells of the vascular wall (Miller et al. 2016; Turner et al. 2016). We find evidence that the SMAD3 intronic SNP rs17293632 affects enhancer activity in ECs, and we further confirm that CRISPR-mediated deletion of the overlapping enhancer leads to significant reduction...
  2. METHODS: In Silico Cloning of Novel Endothelial-Specific Genes
    • Lukasz Huminiecki and
    • Roy Bicknell
    Genome Res. November 1, 2000 10: 1796-1806; doi:10.1101/gr.150700
    ...In Silico Cloning of Novel Endothelial-Specific Genes Lukasz Huminiecki and Roy Bicknell 1 Molecular Angiogenesis Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK...
  3. Research: A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity
    • Bing Zhang,
    • Daniel S. Day,
    • Joshua W. Ho,
    • Lingyun Song,
    • Jingjing Cao,
    • Danos Christodoulou,
    • Jonathan G. Seidman,
    • Gregory E. Crawford,
    • Peter J. Park,
    • and William T. Pu
    Genome Res. June 2013 23: 917-927; Published in Advance April 1, 2013, doi:10.1101/gr.149674.112
    ...of transcriptional programs that distinguish cell states. However, the kinetics of histone modification and their role in mediating rapid, signal-responsive gene expression changes has been little studied on a genome-wide scale. Vascular endothelial growth factor A (VEGFA), a major regulator of angiogenesis...
  4. Research: Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
    • Luciano Pirola,
    • Aneta Balcerczyk,
    • Richard W. Tothill,
    • Izhak Haviv,
    • Antony Kaspi,
    • Sebastian Lunke,
    • Mark Ziemann,
    • Tom Karagiannis,
    • Stephen Tonna,
    • Adam Kowalczyk,
    • Bryan Beresford-Smith,
    • Geoff Macintyre,
    • Ma Kelong,
    • Zhang Hongyu,
    • Jingde Zhu,
    • and Assam El-Osta
    Genome Res. October 2011 21: 1601-1615; Published in Advance September 2, 2011, doi:10.1101/gr.116095.110
    ...of the vascular endothelial epi, which has not been previously examined. A close correspondence between gene expression and chromatinized acetylation was readily explained when the genomic methylation pattern was considered in response to hyperglycemia. Results Massive parallel sequencing reveals regionalized H3K...
  5. LETTER: Cloning, Characterization, and Mapping of a Murine Promiscuous Chemokine Receptor Gene: Homolog of the Human Duffy Gene
    • Hong Luo,
    • Asok Chaudhuri,
    • Kenneth R. Johnson,
    • Kuldeep Neote,
    • Valerie Zbrzezna,
    • Yu He,
    • and A. Oscar Pogo
    Genome Res. September 1, 1997 7: 932-941; doi:10.1101/gr.7.9.932
    ...Cloning, Characterization, and Mapping of a Murine Promiscuous Chemokine Receptor Gene: Homolog of the Human Duffy Gene Hong Luo 1 , Asok Chaudhuri 1 , Kenneth R. Johnson 2 , Kuldeep Neote 3 , Valerie Zbrzezna 1 , Yu He 2...
  6. Resource: A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines
    • David B. West,
    • Ravi K. Pasumarthi,
    • Brian Baridon,
    • Esi Djan,
    • Amanda Trainor,
    • Stephen M. Griffey,
    • Eric K. Engelhard,
    • Jared Rapp,
    • Bowen Li,
    • Pieter J. de Jong,
    • and K.C. Kent Lloyd
    Genome Res. April 2015 25: 598-607; Published in Advance January 15, 2015, doi:10.1101/gr.184184.114
    ...reported, although a role for the Wilms’ tumor protein (WT1) in vascular endothelial cells has been proposed (Scholz et al. 2009; Kirschner et al. 2010). Epithelium and ducts Many mutant reporter genes had epithelial staining, including duct structures, skin, mucosa of the gut, and the airway. WM and FS...
  7. LETTER: Prediction of Cell Type-Specific Gene Modules: Identification and Initial Characterization of a Core Set of Smooth Muscle-Specific Genes
    • Sven Nelander,
    • Petter Mostad,
    • and Per Lindahl
    Genome Res. August 2003 13: 1838-1854; Published in Advance July 17, 2003, doi:10.1101/gr.1197303
    ...Prediction of Cell Type-Specific Gene Modules: Identification and Initial Characterization of a Core Set of Smooth Muscle-Specific Genes Sven Nelander 1 , Petter Mostad 2 , and Per Lindahl 1 , 3 1 Department of Medical Biochemistry...
  8. LETTER: The Zebrafish Annexin Gene Family
    • Steven A. Farber,
    • Robert A. De Rose,
    • Eric S. Olson,
    • and Marnie E. Halpern
    Genome Res. June 2003 13: 1082-1096; doi:10.1101/gr.479603
    ...function, we have cloned 11 zebrafish anx genes. Four genes ( anx1a, anx2a, anx5 ,and anx11a) were identified by screening a zebrafish cDNA library with a Xenopus anx2 fragment. For these genes, full-length cDNA sequences were used to cluster 212 EST sequences generated by the Zebrafish Genome...
  9. LETTER: Early Genetic Mechanisms Underlying the Inhibitory Effects of Endostatin and Fumagillin on Human Endothelial Cells
    • Chiara M. Mazzanti,
    • Anita Tandle,
    • Dominique Lorang,
    • Nick Costouros,
    • David Roberts,
    • Generoso Bevilacqua,
    • and Steven K. Libutti
    Genome Res. August 2004 14: 1585-1593; doi:10.1101/gr.2552804
    ...-suppressor gene. Using InvivoGen technology, we cloned sequences into an RNA polymerase III on the basis of expression vector (psiRNA-Neo) that enabled the endogenous production of small dsRNAs targeting the human DOC1 gene. Endothelial cells were transfected with either the vector containing the DOC1 targeting...
  10. LETTER: Divergence of Spatial Gene Expression Profiles Following Species-Specific Gene Duplications in Human and Mouse
    • Lukasz Huminiecki and
    • Kenneth H. Wolfe
    Genome Res. October 2004 14: 1870-1879; doi:10.1101/gr.2705204
    ...share a surprisingly high proportion of cellular elements, such as vascular cells (endothelial cells, vascular smooth muscles), infiltrating white cells, or cells of the connective tissue. METHODS Sequence Data The Ensembl-confirmed gene protein and nucleotide set were extracted using the EnsMart tool...
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