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  1. ...to process reads from several organisms simultaneously and from each stage of sequencing: shotgun, automated finishing, and the final manual finishing phase. An object-oriented approach lends itself well to these requirements. The serial data flow (Fig. 2 ) also suggests a component-based system similar...
  2. ...for the human , which we refer to as human-grade finished sequence, is substantially better than that available at the end of the shotgun phase. The latter full-shotgun draft sequence is simply derived from the automated assembly of the full collection of shotgun sequence reads (e.g., that providing greater...
  3. ...Res. 10 : 1579 -1586. ↵ Gordon, D., Abajian, C., and Green, P. 1998 . Consed: A graphical tool for sequence finishing. Genome Res. 8 : 195 -202. ↵ Gordon, D., Desmarais, C., and Green, P. 2001 . Automated finishing with autofinish. Genome Res. 11 : 614 -625. ↵ Grahovac, B., Sukernik, R.I., O'hUigin, C...
  4. ...., and Green, P. 2001 . Automated finishing with autofinish. Genome Res. 11 : 614 –625. ↵ Halligan, D.L., Eyre-Walker, A., Andolfatto, P., and Keightley, P.D. 2004 . Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila. Genome Res. 14 : 273 –279. ↵ Harris, M.A., Clark, J., Ireland...
  5. ...finishing. Genome Res. 8 : 195 –202. ↵ Gordon, D., Desmarais, C., and Green, P. 2001 . Automated finishing with autofinish. Genome Res. 11 : 614 –625. ↵ Hoover, E.A. and Mullins, J.I. 1991 . Feline leukemia virus infection and diseases. J. Am. Vet. Med. Assoc. 199 : 1287 –1297. ↵ Hughes, A.L. and Yeager, M...
  6. ....R. 2002 . Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems. J. Mol. Evol. 55 : 37 -51. ↵ Gordon, D., Desmarais, C., and Green, P. 2001 . Automated finishing with autofinish. Genome Res. 11 : 614 -625. ↵ Hacker...
  7. ...enabled a 43-fold increase in the total finished human genomic sequence in the world in the past four years. This is the second half of a two-part, noncomprehensive review that presents an overview of different types of automation equipment used in genome sequencing. The first part of the review...
  8. ...., Abajian, C., and Green, P. 1998 . Consed: A graphical tool for sequence finishing. Genome Res. 8 : 195 -202. ↵ Gordon, D., Desmarais, C., and Green, P. 2001 . Automated finishing with autofinish. Genome Res. 11 : 614 -625. ↵ Green, P., Lipman, D., Hillier, L., Waterston, R., States, D., and Claverie, J...
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