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  1. ...kinase) and protein metabolism (e.g., AL136807, homologous to RAMP4, which itself is involved in protein glycosylation during translocation). Specificity of our assays could be demonstrated by the finding that none of the proteins predicted to be involved in general cellular or nucleic acid metabolism (e...
  2. ...taxa (Fig. 1A). Surveying the NCBI Conserved Domain Database (CDD) with each domain pair using CDART searches (http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd. shtml) identified 11 of the pairs in invertebrates such as bees, Drosophila, or Caenorhabditis elegans (Supplemental Table 3; some genes from...
  3. ...: 1575 –1584. ↵ Florea, L., Hartzell, G., Zhang, Z., Rubin, G.M., and Miller, W. 1998 . A computer program for aligning a CDNA sequence with a genomic DNA sequence. Genome Res. 8 : 967 –974. ↵ Geer, L.Y., Domrachev, M., Lipman, D.J., and Bryant, S.H. 2002 . CDART: Protein homology by domain architecture...
  4. ...of Inhibitor of Apoptosis Proteins (IAPs); (6) Bcl-2 homology (BH) domains of Bcl-2 family proteins; (7) Tumor Necrosis Factor (TNF)-family ligands; (8) TNF receptors (TNFR); (9) TIR domains; (10) PAAD (PYRIN; PYD, DAPIN); (11) nucleotide-binding NACHT domains; (12) TRAFs; (13) Hsp70-binding BAG domains...
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