Searching journal content for articles similar to Geeleher et al..

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  1. Research: Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution
    • Justyna A. Resztak,
    • Julong Wei,
    • Samuele Zilioli,
    • Edward Sendler,
    • Adnan Alazizi,
    • Henriette E. Mair-Meijers,
    • Peijun Wu,
    • Xiaoquan Wen,
    • Richard B. Slatcher,
    • Xiang Zhou,
    • Francesca Luca,
    • and Roger Pique-Regi
    Genome Res. June 2023 33: 839-856; Published in Advance July 13, 2023, doi:10.1101/gr.276765.122
    ...variability and dynamics to gain a better understanding of the molecular underpinnings of inter-individual variation in drug response. Here, we used single-cell RNA-seq to study the dynamics of the transcriptional response to glucocorticoids in activated peripheral blood mononuclear cells from 96 African...
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  2. Research: Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
    • Xia Yang,
    • Bin Zhang,
    • Cliona Molony,
    • Eugene Chudin,
    • Ke Hao,
    • Jun Zhu,
    • Andrea Gaedigk,
    • Christine Suver,
    • Hua Zhong,
    • J. Steven Leeder,
    • F. Peter Guengerich,
    • Stephen C. Strom,
    • Erin Schuetz,
    • Thomas H. Rushmore,
    • Roger G. Ulrich,
    • J. Greg Slatter,
    • Eric E. Schadt,
    • Andrew Kasarskis,
    • and Pek Yee Lum
    Genome Res. August 2010 20: 1020-1036; Published in Advance June 10, 2010, doi:10.1101/gr.103341.109
    ...of drugs, fatty acids, amino acids, and steroids. Genome-wide association analyses between genetic polymorphisms and P450 expression or enzyme activities revealed sets of SNPs associated with P450 traits, and suggested the existence of both cis -regulation of P450 expression (especially for CYP2D6...
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  3. Method: Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation
    • Casey Hanson,
    • Junmei Cairns,
    • Liewei Wang,
    • and Saurabh Sinha
    Genome Res. August 2018 28: 1207-1216; Published in Advance June 13, 2018, doi:10.1101/gr.227066.117
    ..., Minnesota 55905, USA; 3Department of Computer Science and Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA Corresponding authors: sinhas@illinois.edu, Wang.Liewei@mayo.eduAbstractRecent studies have analyzed large-scale data sets of gene expression...
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