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  1. ARTICLES: A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.
    • N J Schork,
    • J E Krieger,
    • M R Trolliet,
    • K G Franchini,
    • G Koike,
    • E M Krieger,
    • E S Lander,
    • V J Dzau,
    • and H J Jacob
    Genome Res. September 1995 5: 164-172; doi:10.1101/gr.5.2.164
    ...with hypertension in spontaneously hypertensive rats. Hypertension 19 : 611 – 614 . Harris, E.L., , Dene, H. , Rapp. J.P. Harris, E.L., Dene, H. and Rapp. J.P. 1993 . SA gene and blood pressure cosegregation using Dahl salt-sensitive rats. Am. J. Hypertension 6 : 330 – 334 . Hashimoto, L., , Habita, C. , Beressi, J...
  2. RESOURCE: BAC Resources for the Rat Genome Project
    • Kazutoyo Osoegawa,
    • Baoli Zhu,
    • Chung Li Shu,
    • Teresa Ren,
    • Qing Cao,
    • Gery M. Vessere,
    • Michelle M. Lutz,
    • Michael I. Jensen-Seaman,
    • Shaying Zhao,
    • and Pieter J. de Jong
    Genome Res. April 2004 14: 780-785; doi:10.1101/gr.2033904
    ...using Dahl salt-sensitive rats. Genome Res. 8 : 711 -723. ↵ Jacob, H.J. and Kwitek, A.E. 2001 . Rat genetics: attaching physiology and pharmacology to the . Nature Rev. Genet. 3 : 33 -42. ↵ Krzywinski, M., Wallis, J., Gösele, C., Bosdet, I., Chiu, R., Graves, T., Hummel, O., Layman, D., Mathewson, C...
  3. LETTER: Using Advanced Intercross Lines for High-Resolution Mapping of HDL Cholesterol Quantitative Trait Loci
    • Xiaosong Wang,
    • Isabelle Le Roy,
    • Edwige Nicodeme,
    • Renhua Li,
    • Richard Wagner,
    • Christina Petros,
    • Gary A. Churchill,
    • Stephen Harris,
    • Ariel Darvasi,
    • Jorge Kirilovsky,
    • Pierre L. Roubertoux,
    • and Beverly Paigen
    Genome Res. July 2003 13: 1654-1664; Published in Advance June 12, 2003, doi:10.1101/gr.1185803
    ...method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69 : 315 -324. ↵ Herrera, V.L., Lopez, L.V., and Ruiz-Opazo, N. 2001 . α 1 Na,K-ATPase and Na,K, 2 Cl-cotransporte/D3Mit3 loci interact to increase susceptibility to salt-sensitive hypertension in Dahl S(HSD) rats...
  4. PERSPECTIVE: Impact of genomics on research in the rat
    • Jozef Lazar,
    • Carol Moreno,
    • Howard J. Jacob,
    • and Anne E. Kwitek
    Genome Res. December 2005 15: 1717-1728; doi:10.1101/gr.3744005
    ...are typically constructed one at a time and then assembled onto multicongenics. View larger version: In this window In a new window Figure 1. Schematic representation of the generation of a congenic strain from two genetically different rat strains. ( A ) Parental strains Brown Norway (BN) and Dahl salt-sensitive...
  5. LETTER: New Target Regions for Human Hypertension via Comparative Genomics
    • Monika Stoll,
    • Anne E. Kwitek-Black,
    • Allen W. Cowley, Jr.,
    • Eugenie L. Harris,
    • Stephen B. Harrap,
    • José E. Krieger,
    • Morton P. Printz,
    • Abraham P. Provoost,
    • Jean Sassard,
    • and Howard J. Jacob
    Genome Res. April 1, 2000 10: 473-482; doi:10.1101/gr.10.4.473
    ..., hopefully, improved therapeutic outcomes. METHODS Linkage Analysis of Hypertension-Related Traits in Various Genetically Hypertensive Rat Intercrosses This study used five different hypertensive rat strains: the spontaneously hypertensive rat (SHR); the Dahl salt-sensitive rat rederived at the Medical...
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