Searching journal content for articles similar to Galtier et al. 16 (2): 215.

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  1. ...mitochondrial and cytosolic translation, as well as in mitochondrial respiration.The flow of genetic information from DNA to protein entails multiple highly regulated steps from mRNA transcription, processing, and export to translation into proteins with subsequent folding, post-translational modification, and...
  2. ...accumulation on phenotype in more than 20 generations of wild-type C57BL/6 mice and mutator mice, which have high DNA replication error rates. We estimated the base-substitution mutation rate to be 5.4 × 10−9 (95% confidence interval = 4.6 × 10−9–6.5 × 10−9) per nucleotide per generation in C57BL/6 laboratory...
  3. ...of the Saccharomyces cerevisiae DNA damage-responsive kinase Tel1 (ortholog of mammalian ATM). A tel1Δ mutant has globally increased amounts of Spo11-oligonucleotide complexes and altered Spo11-oligonucleotide lengths, consistent with conserved roles for Tel1 in control of DSB number and processing. A kinase-dead tel1...
  4. ...DNA ligase 3 and 4 double-knockouts. We reveal distinct mutational signatures associated with classical NHEJ-mediated inter-chromosomal, as opposed to alternative NHEJ-mediated intra-chromosomal, telomere fusions and evidence for an unanticipated sufficiency of DNA ligase 1 for these intra...
  5. ...-eighties, when short mitochondrial DNA (mtDNA) fragments were successfully cloned and sequenced from museum specimens of the quagga (Equus quagga)—an equid that became extinct in South Africa at the end of the 19th century. The findings demonstrated that trace nucleic acids survive at least over the time frame...
  6. ...in functionally important regions are more likely to be deleterious and are more readily eliminated from the population by purifying selection than mutations in ‘junk DNA.’ Nonfunctional nucleotides therefore accumulate fixed mutations more quickly, and diverge more rapidly during the course of evolution, than do...
  7. ...mutations, associated with the gradual amelioration of the integrated sequence to the nucleotide composition of the host chromosome. Deletion of organelle DNA at these loci is essentially balanced by insertions of nonorganelle DNA. Deletions are associated with the removal of DNA between perfect repeats...
  8. ...and replication. Indeed, it was shown that sequences with many ATs and TAs have lower recombination rates than those containing AGs, TCs, CAs, and TGs (Guo et al. 2009). Thus, we explored the possibility that ULEs are enriched at recombination hot spots (RHSs). RHSs are DNA regions with a higher rate of meiotic...
  9. ...mammalian species. Modern mammals comprise three major lineages ( Fig. 1 ). Judged from multiple nuclear sequence and mtDNA alignments, the most closely related of these, the Metatheria and Eutheria (placental mammals), diverged from their most recent common ancestor ∼173–190 million years ago (Mya) ( Kumar...
  10. ...have focused mainly on variations of mitochondrial DNA or VNTRs ( Vila et al. 1997 ; Savolainen et al. 2002 ; Koskinen 2003 ; Parker et al. 2004 ). These approaches indicate that modern dog breeds were first domesticated from wolves, possibly in East Asia, and that many dog breeds that share...
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