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  1. ...↵Daubin V, Ochman H. 2004b. Start-up entities in the origin of new genes. Curr Opin Genet Dev 14: 616–619. doi:10.1016/j.gde.2004.09.004 ↵de Souza GA, Søfteland T, Koehler CJ, Thiede B, Wiker HG. 2009. Validating divergent ORF annotation of the Mycobacterium leprae through a full translation data set...
  2. ...G dinucleotides, as experimental evidence supports the longterm survival of methylated cytosines (5mC) in aDNA fragments (Briggs et al. 2010; Llamas et al. 2012). Genome-wide methylationmaps of the human have already been reconstructed using high-throughput sequencing in combination with a variety of approaches...
  3. ...), or that synonymous substitutions might be not always silent ( Graur and Li 2000 ). Interestingly, a similar interaction between the level of expression, the level of codon bias, and gene conservation (both synonymous and nonsynonymous) was demonstrated in Mycobacterium sp. ( de Miranda et al. 2000 ), supporting...
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