Searching journal content for articles similar to Frazer et al. 14 (8): 1493.

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  1. .... 2023).The phylogenetic trees also provide a rich genomic landscape to explore possible regions of cryptic genetic variation among strains; namely, variation that may have little effect on phenotypic variation within populations but may contribute to trait heritability across populations (Paaby...
  2. ...from different subpopulations can be observed, although each principal component only explains a very small proportion of the variation between individuals, indicating that genetic differentiation is low.We annotated 17,728 SNPs across 2886 genomic scaffolds using the Ensembl variant effect predictor...
  3. ...gigabases of sequence across 21 chromosomes. Meiotic crossovers are highly polarized along the chromosomes, with elevation in the gene-dense distal regions and suppression in the Gypsy retrotransposon-dense centromere-proximal regions. We profiled the genomic landscapes of the meiotic recombinase DMC1...
  4. ...). In the most extreme case, we found a 717-kb unique and nonrepetitive consecutive sequence in the region between the SNPs at position 91,144,048 and 91,861,518 on chromosome 14 that lacked any SNP or short indel between B6 and JF1. To determine whether these blocks are widely distributed across the B6 , we...
  5. ..., but also human-specific nonpolymorphic regions, that is, genomic regions that present structural polymorphism in all great apes, but are either fixed or present only rare and even pathogenic variants in humans. Results Comparing CNVs across species A total of 51 individuals from the four great ape species...
  6. ...that hybridization intensity is not strongly affected until there are at least four to five SNPs within the probe sequence. This level of polymorphism spread across multiple portions of the coding region would represent a highly divergent allele. Analysis of the array CGH data identified 479 UpCNV genes and 3410...
  7. ...contribution methods to maintain diversity, fitness, and selection signatures. Maximum genetic diversity was maintained using marker-by-marker coancestry, and least using genealogical coancestry. Using a measure of coancestry based on shared segments of the genome achieved the best results in terms...
  8. ...of genomic sequence in 13 laboratory inbred strains and 12 wild-derived inbred strains. Variation in haplotype block size has also been reported in two recent studies ( Frazer et al 2004 ; Yalcin et al. 2004 ) based on analyses of ∼5 Mb of fine-resolution haplotype structure across multiple strains...
  9. ...divergence Genomic sequence features, including GC content, repetitive elements, and gene density, correlatewith variation in recombination rate across single s (Kong et al. 2002; Jensen-Seaman et al. 2004; Myers et al. 2005; Shifman et al. 2006). The well-curated sequence of the house mouse, combined...
  10. ...ancestrally inbred populations (Boyko et al. 2010). The Isle Royale National Park and Mexican wolves had the highest fraction of autozygous segments across all fragment sizes, as well as the highest r20.5 (Fig. 5). The red wolf had elevated ROH relative to the outbred gray wolf and coyote populations; however...
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