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Corrigendum: Corrigendum: Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
- Lee H. Wong,
- Kate H. Brettingham-Moore,
- Lyn Chan,
- Julie M. Quach,
- Melissa A. Anderson,
- Emma L. Northrop,
- Ross Hannan,
- Richard Saffery,
- Margaret L. Shaw,
- Evan Williams,
- and K.H. Andy Choo
Genome Res. June 2024 34: 979-980; doi:10.1101/gr.279693.124
...to these panels has also been modified in the Results section (pages 1147–1149) and in the figure legend (see below). These corrections do not alter the conclusions of the article. The authors apologize for any confusion. Centromere RNA accumulates in the transcriptionally active nucleolus “The results...
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Research: Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction
- Laura Blanco-Berdugo,
- Alexis Garretson,
- and Beth L. Dumont
Genome Res. January 2026 36: 50-60; Published in Advance November 13, 2025, doi:10.1101/gr.281180.125
...mutagens can alter the spectrum of mutations that accumulate in somatic tissues (Pleasance et al. 2010; Alexandrov et al. 2020), prompting us to ask whether the altered hormonal milieu and in vitro environment encountered during the generation of ART-born mice modify the prevalence of specific types...
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Research: The rate and spectrum of new mutations in mice inferred by long-read sequencing
- Eugenio López-Cortegano,
- Jobran Chebib,
- Anika Jonas,
- Anastasia Vock,
- Sven Künzel,
- Peter D. Keightley,
- and Diethard Tautz
Genome Res. January 2025 35: 43-54; Published in Advance December 2, 2024, doi:10.1101/gr.279982.124
...microsatellite sequence motif was AGAT (>44%, Supplemental Fig. S7B), highlighting its hypermutability in mice. Our data do not, however, allow us to determine whether modifiers of the indel rate are present in any of the strains (Maksimov et al. 2023). Regarding indels of other lengths, 95.5% involved...
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Research: Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice
- Leandros Boukas,
- Teresa Romeo Luperchio,
- Afrooz Razi,
- Kasper D. Hansen,
- and Hans T. Bjornsson
Genome Res. May 2024 34: 696-710; Published in Advance May 3, 2024, doi:10.1101/gr.278416.123
...modelsWe performed ATAC-seq in order to characterize the -wide chromatin accessibility landscape in KS mice (both type 1 and type 2) and wild-type littermates (Methods). We examined sorted hippocampal neurons from the dentate gyrus (henceforth, neurons) and sorted peripheral T cells (Methods). We also...
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Method: Characterization of meiotic recombination intermediates through gene knockouts in founder hybrid mice
- Benjamin Davies,
- Gang Zhang,
- Daniela Moralli,
- Samy Alghadban,
- Daniel Biggs,
- Chris Preece,
- Peter Donnelly,
- and Anjali Gupta Hinch
Genome Res. November 2023 33: 2018-2027; Published in Advance November 17, 2023, doi:10.1101/gr.278024.123
...al. 2016; Hinch et al. 2019, 2020; Li et al. 2019; Gergelits et al. 2021). The ability to extend this approach to genetically modified mice is a tool of obvious power, as it could illuminate the consequences of loss of function of key meiotic genes -wide, specifically and separately for sites...
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Research: Centromere location in Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence
- Shamoni Maheshwari,
- Takayoshi Ishii,
- C. Titus Brown,
- Andreas Houben,
- and Luca Comai
Genome Res. March 2017 27: 471-478; Published in Advance February 21, 2017, doi:10.1101/gr.214619.116
.... ↵Chmátal L, Gabriel SI, Mitsainas GP, Martínez-Vargas J, Ventura J, Searle JB, Schultz RM, Lampson MA. 2014. Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice. Curr Biol 24: 2295–2300. ↵Cooper JL, Henikoff S. 2004. Adaptive evolution of the histone...
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Method: Rapid molecular assays to study human centromere genomics
- Rafael Contreras-Galindo,
- Sabrina Fischer,
- Anjan K. Saha,
- John D. Lundy,
- Patrick W. Cervantes,
- Mohamad Mourad,
- Claire Wang,
- Brian Qian,
- Manhong Dai,
- Fan Meng,
- Arul Chinnaiyan,
- Gilbert S. Omenn,
- Mark H. Kaplan,
- and David M. Markovitz
Genome Res. December 2017 27: 2040-2049; Published in Advance November 15, 2017, doi:10.1101/gr.219709.116
..., Ann Arbor, Michigan 48109, USA; 11Program in Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA; 12Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA Corresponding authors: rafaelc@med.umich.edu, dmarkov@umich.eduAbstractThe centromere...
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Research: Variation in histone configurations correlates with gene expression across nine inbred strains of mice
- Anna L Tyler,
- Catrina Spruce,
- Romy Kursawe,
- Annat Haber,
- Robyn L Ball,
- Wendy A Pitman,
- Alexander D Fine,
- Narayanan Raghupathy,
- Michael Walker,
- Vivek M Philip,
- Christopher L Baker,
- J. Matthew Mahoney,
- Gary A. Churchill,
- Jennifer J Trowbridge,
- Michael L Stitzel,
- Kenneth Paigen,
- Petko M Petkov,
- and Gregory W Carter
Genome Res. May 22, 2023 gr.277467.122; Published in Advance May 22, 2023, doi:10.1101/gr.277467.122
...Variation in histone configurations correlates with gene expression1 across nine inbred strains of mice2 Anna L. Tyler1,∗, Catrina Spruce1,∗, Romy Kursawe2, Annat Haber2, Robyn L. Ball1, Wendy4 A. Pitman1, Alexander D. Fine1, Narayanan Raghupathy1, Michael Walker1, Vivek M. Philip1,5 Christopher L...
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Research: A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice
- Mikhail O. Maksimov,
- Cynthia Wu,
- David G. Ashbrook,
- Flavia Villani,
- Vincenza Colonna,
- Nima Mousavi,
- Nichole Ma,
- Lu Lu,
- Jonathan K. Pritchard,
- Alon Goren,
- Robert W. Williams,
- Abraham A. Palmer,
- and Melissa Gymrek
Genome Res. May 2023 33: 689-702; Published in Advance May 1, 2023, doi:10.1101/gr.277576.122
...on Chromosome 13 at which strains inheriting the C57BL/6J (B) haplotype have a higher rate of STR expansions than those inheriting the DBA/2J (D) haplotype. The strongest candidate gene in this locus is Msh3, a known modifier of STR stability in cancer and at pathogenic repeat expansions in mice and humans...
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LETTER: Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
- Lee H. Wong,
- Kate H. Brettingham-Moore,
- Lyn Chan,
- Julie M. Quach,
- Melissa A. Anderson,
- Emma L. Northrop,
- Ross Hannan,
- Richard Saffery,
- Margaret L. Shaw,
- Evan Williams,
- and K.H. Andy Choo
Genome Res. August 2007 17: 1146-1160; Published in Advance July 10, 2007, doi:10.1101/gr.6022807
...Institute &amp; Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Parkville 3052, Victoria, Australia; 2 Peter MacCallum Research Institute, St. Andrew’s Place, East Melbourne, Victoria 3002, Australia Abstract The centromere is a complex structure, the components and assembly...
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