Searching journal content for articles similar to Fafard-Couture et al. 33 (4): 525.

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  1. ...to be located on the autosomal arms, whereas conserved ones are predominantly found in the centers (Rockman and Kruglyak 2009). To determine whether the enriched ubiquitin-ligase-adaptor genes show any chromosomal distribution bias, we analyzed their genomic locations across C. nigoni strains. Although...
  2. ...and losing their transposition ability (Fedoroff 2012). Despite the majority of TEs becoming silenced, the remaining TE sequences may still contain regulatory motifs or protein domains (Capy 2021). These sequences can be co-opted by the cell machinery, modifying gene expression or protein sequences...
  3. ..., for example, by point mutations or the addition of extra structural motifs, “embellishments,” to a highly conserved structural core (Dessailly et al. 2010). A majority of the most diverse superfamilies have enzyme functions, and much of the functional variation arises from differences in substrate specificity...
  4. ...regulation of mitochondrial–nuclear gene expression (CMNGE) to changing physiological conditions is poorly understood and is limited to certain tissues and organisms. We hypothesized that CMNGE is important for development across vertebrates and, hence, should be conserved. As a first step, we analyzed more...
  5. ...-loops frequently colocalize with binding sites for the architectural protein CTCF, where they can strengthen the binding of CTCF to its consensus motifs in conjunction with G4 structures that form on the single-stranded component (Luo et al. 2022; Wulfridge et al. 2023). The association between CTCF and G4...
  6. ...sequence is functional, the reporter gene is expressed/induced and the cellular concentration of the gene product is measured (Smale 2010).TF binding predictionTFs bind DNA in a sequence-specific manner based on motifs, with each binding site having a consensus sequence that indicates prerequisites...
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  7. ...across the tree of life.Previous studies have shown a correlation between G4 sequence composition in viruses and their hosts (Li et al. 2022). We therefore investigated if the viruses with the highest G4 motif densities also have hosts with a high G4 motif density. Out of the 63,658 viral s that we...
  8. ...experimental workflows, making the simultaneous analysis of transcriptomes and small RNAs affordable and efficient.ResultsGene expression changes determined using sRNA-seq data correlate with RNA-seq across a range of human tissuesTo investigate the potential of sRNA-seq for the analysis of protein coding gene...
  9. ...using Telofinder, a script designed to specifically detect the degenerated yeast telomere motif TG1–3/C1–3A (O'Donnell et al. 2023). Finally, after filtering steps ensuring that the telomere sequences are not truncated or internal (Supplemental Fig. S1A), the lengths of all validated telomere sequences...
  10. ...to a whole TCTA motif loss. This is also evident from the count of different motifs across different reads (Supplemental Fig. 12B). This analysis allows one to assess somatic stability and/or the propensity for technical sequencing errors in a region. Additionally, we randomly selected 8, 15, and 30 reads...
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