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  1. ...in several concatemers (Fig. 6). A similar arrangement of genes, repeats, and gene contents is known to occur in small mobile elements that can “hijack” helper-phage packaging machinery, called phage-inducible chromosomal islands (PICIs) (Penades and Christie 2015). In particular, the integrases and DNA...
  2. ...containing programmed frameshifts (such as the prfB gene encoding a translation initiation factor [Craigen and Caskey 1986], or genes regulating some mobile elements [Sharma et al. 2011]). Furthermore, pseudogenes, especially expressed pseudogenes, could mislead gene-finding tools into generating predictions...
  3. ...for the repeat resolution approach in metaSPAdes described below. Analyzing filigree edges in the assembly graph In addition to single-nucleotide variants and small indels, strain variation is oftenmanifested as highly diverged regions, insertions of mobile elements, rearrangements, large deletions, parallel...
  4. ...Frankia ( Fig. 1 ; Clawson et al. 2004 ). Genome characteristics The s from ACN and CcI3 have been finished, and that from EAN has been rendered in a single scaffold with some gaps corresponding to regions that have proven difficult to resolve due to sequence repeats and high GC content ( Table 2...
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