Searching journal content for articles similar to Eeckhoute et al. 19 (3): 372.

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  1. Research: Cytosine modifications modulate the chromatin architecture of transcriptional enhancers
    • Elise A. Mahé,
    • Thierry Madigou,
    • Aurélien A. Sérandour,
    • Maud Bizot,
    • Stéphane Avner,
    • Frédéric Chalmel,
    • Gaëlle Palierne,
    • Raphaël Métivier,
    • and Gilles Salbert
    Genome Res. June 2017 27: 947-958; Published in Advance April 10, 2017, doi:10.1101/gr.211466.116
    ...1 and 5hmC levels of FOXA1-bound enhancers -wide revealed that 5hmC and TET levels were inversely correlated for three clusters out of four (Fig. 5), suggesting that high TET residency may indeed be associated with high 5hmC superoxidation. Hence, FOXA1 binding to enhancersmight favor the engagement...
  2. Research: Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers
    • Aurélien A. Sérandour,
    • Stéphane Avner,
    • Frédéric Percevault,
    • Florence Demay,
    • Maud Bizot,
    • Céline Lucchetti-Miganeh,
    • Frédérique Barloy-Hubler,
    • Myles Brown,
    • Mathieu Lupien,
    • Raphaël Métivier,
    • Gilles Salbert,
    • and Jérôme Eeckhoute
    Genome Res. April 2011 21: 555-565; Published in Advance January 13, 2011, doi:10.1101/gr.111534.110
    ...the DNA methylation data (Heintzman et al. 2009). Since enhancers are highly cell type specific, this might explain why these regions did not show DNA hypomethylation in this study (Heintzman et al. 2009). In contrast, our data indicating that FOXA1-bound enhancers consist of locally DNA hypomethylated...
  3. Letter: A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae
    • Luke E. Berchowitz,
    • Sean E. Hanlon,
    • Jason D. Lieb,
    • and Gregory P. Copenhaver
    Genome Res. December 2009 19: 2245-2257; Published in Advance October 2, 2009, doi:10.1101/gr.096297.109
    ...recombination are likely to be influenced by chromatin organization (Wu and Lichten 1994; Fan and Petes 1996; Kirkpatrick et al. 1999b). The fundamental unit of chromatin, the nucleosome, is defined as ;146 bp of DNA wrapped around a histone octamer (Luger et al. 1997). Modulation of nucleosome occupancy...
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  4. Research: GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility
    • Vasiliki Theodorou,
    • Rory Stark,
    • Suraj Menon,
    • and Jason S. Carroll
    Genome Res. January 2013 23: 12-22; Published in Advance November 21, 2012, doi:10.1101/gr.139469.112
    ...is that GATA3mediates chromatin loops between FOXA1-bound enhancers and other cis-regulatory elements (indirect FOXA1-binding regions), which may explain why silencing ofGATA3 influences FOXA1 and ESR1 at specific regions. However, it is clearly evident that there are functional consequences of GATA3 silencing...
  5. Research: Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver
    • Brad G. Hoffman,
    • Gordon Robertson,
    • Bogard Zavaglia,
    • Mike Beach,
    • Rebecca Cullum,
    • Sam Lee,
    • Galina Soukhatcheva,
    • Leping Li,
    • Elizabeth D. Wederell,
    • Nina Thiessen,
    • Mikhail Bilenky,
    • Timothee Cezard,
    • Angela Tam,
    • Baljit Kamoh,
    • Inanc Birol,
    • Derek Dai,
    • YongJun Zhao,
    • Martin Hirst,
    • C. Bruce Verchere,
    • Cheryl D. Helgason,
    • Marco A. Marra,
    • Steven J.M. Jones,
    • and Pamela A. Hoodless
    Genome Res. August 2010 20: 1037-1051; Published in Advance June 15, 2010, doi:10.1101/gr.104356.109
    ...that the regulated presence of H3K4me1-marked nucleosomes at transcription factor occupied promoters and enhancers controls their activity, implicating both tissue-specific transcription factor binding and nucleosome remodeling complex recruitment in determining tissue-specific gene expression. Finally, we apply...
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