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  1. .... , Volaufova, J. , Zuberi, A. , Richards, B.K. ( 2007 ) Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: Congenic strain confirmation and candidate gene analyses ( Glo1 , Glp1r ) Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 : R207 – R216 . ↵ Li, J. , Jiang, T. , Mao...
  2. ...of complex traits and disease models. [Supplemental material is available for this article.] Genetics of complex traits and disease Mutations have been identified inmore than 5000 genes that lead to monogenic disease in humans (Chen et al. 2013). These discoveries have revolutionized the diagnosis of single-gene...
  3. ...createdmore onerously by targeted deletion of genes (Austin et al. 2004) or by chemical mutagenesis (Hrabe de Angelis et al. 2000; Nolan et al. 2000). Flint and Mackay 726 Genome Research www..org Analyses of effects of P-element mutations on quantitative traits have revealed that many genes that play a major...
  4. ..., unpubl.). The conventional strategy for identification of modifier or QTL candidate genes requires the creation of congenic animals, followed by mapping the trait in question in a series of subcongenic intervals. This method, although effective, is slow and laborious, entailing significant time, animal...
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