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  1. ...Quantification of GC-biased gene conversion in the human Sylvain Glémin1,2, Peter F. Arndt3, Philipp W. Messer4, Dmitri Petrov5, Nicolas Galtier1 and Laurent Duret6 1Institut des Sciences de l'Evolution (ISEM - UMR 5554 Université de Montpellier-CNRS-IRD-EPHE), 34095 Montpellier, France; 2...
  2. ...of male-driven biased gene conversion. Genome Res 17: 1420–1430. Duret L, Arndt PF. 2008. The impact of recombination on nucleotide substitutions in the human . PLoS Genet 4: e1000071. Dutheil J, Gaillard S, Bazin E, Glemin S, RanwezV, Galtier N, Belkhir K. 2006. Bio++: A set of C++ libraries for sequence...
  3. ...and Duret 2004). Specifically, this can be explained by the process of biased gene conversion, i.e., the tendency for the double-strand break repair mechanism to preferably insert C or G, rather than A or T, at mismatch positions (Marais 2003). On the other hand, data from higher primates indicate...
  4. ...with the long-term action of biased gene conversion on the dog lineage. These results are consistent with the loss of PRDM9 in canids, resulting in a greater evolutionary stability of recombination hotspots. The genetic determinants of recombination hotspots in the dog genome may thus reflect a fundamental...
  5. ...composition. Compared with ratebasedmethods, SiPhymay also bemore influenced by phenomena more directly associated with mutation and repair than with natural selection, such as transcription-coupled repair (Green et al. 2003), biased gene conversion (Marais 2003; Dreszer et al. 2007), Figure 5. Distributions...
  6. ...of recombination in regions of high GC content. Subtelomeric regions appear to fit this same pattern, with elevated divergence and recombination rates. Dreszer et al. (2007) found evidence that biased gene conversion has major contributions to elevated substitution rates in conjunction with high GC content...
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