Searching journal content for articles similar to Dombrovsky et al. 19 (11): 2052.

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  1. ...of the mammalian . We use whole- sequencing to identify de novo mutations in cohorts of age-matched ART-derived and naturally conceived mice. Our reliance on mice of a single inbred strain background allows us to rigorously control for potential genetic influences and environmental exposures on mutation rates...
  2. ...in length during reproduction but are not yet at the disease threshold. These alleles often have altered methylation, challenging to measure with methylation-sensitive restriction-based assays, but which has shown an association between repeat length, methylation percentage, and phenotype severity (Pretto...
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  3. ...in PD (Hindle 2010; Reeve et al. 2014; Collier et al. 2017). In addition, genetic susceptibility and environmental exposures are believed to interact with age-related cellular decline to influence disease onset and progression (Pang et al. 2019). Despite aging being the greatest risk factor...
  4. ...k-mer cross-species profiling reveals taxon-specific TE expansions accompanied 1 by KZFP co-option and functional impacts in ruminants 2 3 Pengju Zhao1,2*, Jiayi He1,2, Chen Peng1,2, Yuelang Zhang1,2, Chong Wang1,2, 4 Dongyou Yu1,2, Lingzhao Fang3*, Zhengguang Wang1,2* 5 6 1Hainan Institute...
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  5. ...@milaboratories.comAbstractAllelic variability in the adaptive immune receptor loci, which harbor the gene segments that encode B cell and T cell receptors (BCR/TCR), is of critical importance for immune responses to pathogens and vaccines. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread in immunology research...
  6. ...Strain-level metagenomic profiling using pan graphs with PanTax Wenhai Zhang1,2,5, Yuansheng Liu3,5, Guangyi Li2,5, Jialu Xu2, Enlian Chen2, Alexander Schönhuth4 and Xiao Luo1,2 1Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, Hunan 410082, China; 2...
  7. ...Corresponding author: michael.werner@utah.eduAbstractDevelopmental plasticity enables the production of alternative phenotypes in response to different environmental conditions. Although significant advances in understanding the ecological and evolutionary implications of plasticity have been made...
  8. ...-DNA insertion mutants exhibit no observable phenotype compared to wild-type plants (Kanno et al. 2018). The paralogs LAZY1/LAZY6 in Arabidopsis (Supplemental Fig. S13F) also illustrate this pattern: LAZY1 (LDO) controls shoot orientation as in rice, whereas LAZY6 (MDO) has a different expression profile...
  9. ...a systematic comparison between single-cell long-read and conventional short-read RNA sequencing techniques. The transcriptome of approximately 30,000 mouse retina cells was profiled using 1.54 billion Illumina short reads and 1.40 billion Oxford Nanopore Technologies long reads. Consequently, we identify 44...
  10. ...(Li et al. 2016; Kusmec et al. 2017).Environmental variables including temperature, day length, and precipitation influence important plant phenotypes via phenotypic plasticity (Des Marais et al. 2013; Blackman 2017; Scheres and van der Putten 2017). Perhaps the best-known example is growing degree...
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