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  1. ...discrimination of mammalian conserved non-genic sequences (CNGs). Science 302 : 1033 -1035. ↵ Dermitzakis, E.T., Kirkness, E., Schwarz, S., Birney, E., Reymond, A., and Antonarakis, S.E. 2004 . Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog s shows...
  2. ...indicates that they are dosage sensitive and that there are selective constraints to keep them single copy. ULEs are under purifying selection and not mutational cold spots The high sequence conservation of ULEs between Arabidopsis and Vitis indicates that ULEs are selectively constrained sequences. Figure...
  3. ...( Kleinjan and van Heyningen 2005 ). Identifying putative CRMs computationally relies on phylogenetic footprinting (for overview, see Ureta-Vidal et al. 2003 ) with sequence conservation implying functional constraint, although the confidence of such predictions depends on the evolutionary distance between...
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