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  1. ...expression at the transcript level effectively reduces noise. As proof of principle, we applied this strategy to mouse embryonic stem cells and successfully captured the expression profile of endogenous retroviruses in single cells. We further expanded our analysis to scRNA-seq data from early stages...
  2. ...DNA gene expression is generally elevated across evolutionTo assess the dynamics of mitochondrial transcript regulation during metazoan development, we have analyzed publicly available bulk RNA-seq data from six mammals—Homo sapiens, human; Macaca mulatta, rhesus monkey; Mus musculus, mouse; Rattus...
  3. ...-related change that occur across different genetic backgrounds and can associate heterogeneity in aging traits to genetic loci. We analyze transcriptome data from RNA sequencing (RNA-seq) and proteome data from mass spectrometry of heart tissues collected from healthy DO mice at ages 6, 12, and 18 mo. At 6 mo...
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