Searching journal content for articles similar to Das et al. 25 (12): 1886.

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  1. Corrigendum: Corrigendum: Replication timing is regulated by the number of MCMs loaded at origins
    • Shankar P. Das,
    • Tyler Borrman,
    • Victor W.T. Liu,
    • Scott C.-H. Yang,
    • John Bechhoefer,
    • and Nicholas Rhind
    Genome Res. December 2016 26: 1761; doi:10.1101/gr.216945.116
    ...of MCMs loaded at origins Genome Research 25: 1886–1892 (2015) Corrigendum: Replication timing is regulated by the number of MCMs loaded at origins Shankar P. Das, Tyler Borrman, Victor W.T. Liu, Scott C.-H. Yang, John Bechhoefer, and Nicholas Rhind The authors would like to correct the omission...
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  2. Method: Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase
    • Jared M. Peace,
    • Sandra K. Villwock,
    • John L. Zeytounian,
    • Yan Gan,
    • and Oscar M. Aparicio
    Genome Res. March 2016 26: 365-375; Published in Advance January 4, 2016, doi:10.1101/gr.196857.115
    ...of origin timing regulation by identifying Fkh1 and Fkh2 as rate-limiting factors for origin firing that determine the ability of replication origins to accrue limiting factors and have the potential to reprogram replication timing late in G1 phase. [Supplemental material is available for this article...
  3. Research: Rtt109 slows replication speed by histone N-terminal acetylation
    • Nelly Frenkel,
    • Felix Jonas,
    • Miri Carmi,
    • Gilad Yaakov,
    • and Naama Barkai
    Genome Res. March 2021 31: 426-435; Published in Advance February 9, 2021, doi:10.1101/gr.266510.120
    ...; Owen-Hughes and Gkikopoulos 2012).DNA replication is initiated from hundreds of sites that are distributed across the (Bell and Dutta 2002). These replication origins are bound by the origin recognition complex (ORC), which recruits the MCM complex and thus initiates assembly of the replication...
  4. Method: Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins
    • Dimiter Kunnev,
    • Amy Freeland,
    • Maochun Qin,
    • Robert W. Leach,
    • Jianmin Wang,
    • Rajani M. Shenoy,
    • and Steven C. Pruitt
    Genome Res. April 2015 25: 558-569; Published in Advance March 11, 2015, doi:10.1101/gr.176099.114
    ...the origin recognition complex (ORC), CDC6, and CDT1 load an inactive form of the minichromosome maintenance (MCM) 2-7 hexameric helicase onto chromatin to form pre-replication complexes (Masai et al. 2010). Unlike other components of the pre-replication complex that bind only transiently, once MCM proteins...
  5. Research: Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing
    • Gaetano Ivan Dellino,
    • Davide Cittaro,
    • Rossana Piccioni,
    • Lucilla Luzi,
    • Stefania Banfi,
    • Simona Segalla,
    • Matteo Cesaroni,
    • Ramiro Mendoza-Maldonado,
    • Mauro Giacca,
    • and Pier Giuseppe Pelicci
    Genome Res. January 2013 23: 1-11; Published in Advance November 27, 2012, doi:10.1101/gr.142331.112
    ...Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing Gaetano Ivan Dellino 1 , 2 , 11 , Davide Cittaro 3 , 6 , Rossana Piccioni 1 , Lucilla Luzi 4...
  6. Research: Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans
    • Maude Strobino,
    • Joanna M. Wenda,
    • Laura Padayachy,
    • and Florian A. Steiner
    Genome Res. December 2020 30: 1740-1751; Published in Advance November 10, 2020, doi:10.1101/gr.260794.120
    ...to determine replication timing, map replication origins, and examine replication fork progression. Our analysis of the spatiotemporal regulation of DNA replication shows that despite the very rapid embryonic cell cycle, the is replicated from early and late firing origins and is partitioned into domains...
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  7. Research: Noncoding transcription influences the replication initiation program through chromatin regulation
    • Julien Soudet,
    • Jatinder Kaur Gill,
    • and Françoise Stutz
    Genome Res. December 2018 28: 1882-1893; Published in Advance November 6, 2018, doi:10.1101/gr.239582.118
    ...transcription redistributes the MCM helicases from their ORC binding initial site of loading. Since we have established widespread noncoding transcription as a novel primordial parameter regulating replication initiation in S. cerevisiae, its importance for the metazoan replication program warrants future study...
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  8. Research: Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features
    • Christelle Cayrou,
    • Philippe Coulombe,
    • Alice Vigneron,
    • Slavica Stanojcic,
    • Olivier Ganier,
    • Isabelle Peiffer,
    • Eric Rivals,
    • Aurore Puy,
    • Sabine Laurent-Chabalier,
    • Romain Desprat,
    • and Marcel Méchali
    Genome Res. September 2011 21: 1438-1449; Published in Advance July 12, 2011, doi:10.1101/gr.121830.111
    ...in mouse (Hiratani et al. 2008), suggesting that replication timing is controlled by Ori density. Figure 3. Association of replication origins with CGI in metazoans. Example of replication origins associated with CGI in (A) mouse ES cells and (C ) Drosophila cells. The percentage of CGI/replication origin...
  9. Research: Common genomic elements promote transcriptional and DNA replication roadblocks
    • Kevin Roy,
    • Jason Gabunilas,
    • Abigail Gillespie,
    • Duy Ngo,
    • and Guillaume F. Chanfreau
    Genome Res. October 2016 26: 1363-1375; Published in Advance August 18, 2016, doi:10.1101/gr.204776.116
    ...or equal to twofold up-regulation over WT). Roy et al. 1370 Genome Research www..org Importantly, residence time was a better predictor for Rap1p function than occupancy measured by traditional ChIP. To study how Rap1p dynamics might be affected by Pol II collision, we screened Rap1p sites for roadblock...
  10. Research: Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila
    • Robin L. Armstrong,
    • Taylor J.R. Penke,
    • Brian D. Strahl,
    • A. Gregory Matera,
    • Daniel J. McKay,
    • David M. MacAlpine,
    • and Robert J. Duronio
    Genome Res. November 2018 28: 1688-1700; Published in Advance October 2, 2018, doi:10.1101/gr.239913.118
    ...posit that these features of organization regulate replication by influencing trans-acting factor recruitment to sites of replication initiation (i.e., origins) (Mantiero et al. 2011; Collart et al. 2013; Pope et al. 2014; Das et al. 2015; Miotto et al. 2016; Rivera-Mulia and Gilbert 2016). In all...
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