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  1. ..., both inactive and active retrotransposons drive genome evolution and may influence transcription through various mechanisms. In humans, three retrotransposon families are still active, but one of these, SVA, remains mysterious. Here we report the identification of a new subfamily of SVA, which...
  2. ...a much lower density and Chromosomes 18, 19, and 22 a higher density (Fig. 4). An uneven distribution of non-LTR retrotransposons across the chromosomes has been observed previously (e.g., SVA or Alu elements) (International Human Genome Sequencing Consortium 2001; Wang et al. 2005). Origin of the Platy...
  3. ....01.019 ↵Damert A, Raiz J, Horn AV, Löwer J, Wang H, Xing J, Batzer MA, Löwer R, Schumann GG. 2009. 5′-Transducing SVA retrotransposon groups spread efficiently throughout the human . Genome Res 19: 1992–2008. doi:10.1101/gr.093435.109 ↵Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, White R. 1990. Centre d...
  4. ...repression and DNA methylation of an SVA retrotransposon reporter. By using naıv̈e versus primed mouse pluripotent stem cells, we reveal a critical role for the HUSH complex in naıv̈e cells, implicating it in programming epigenetic marks in development. Although the HUSH component FAM208A binds to endogenous...
  5. ...of tandem repeats (VNTR)-Alu (SVAs). ERVs and LINEs encode the reverse transcriptase and endonuclease activities necessary for their retrotransposition, whereas the nonautonomous SINE and SVA elements rely on LINE proteins for spreading. Due respectively to internal recombination and abortive...
  6. ...with older family members (types A–D) than with their younger, human-restricted counterparts (types E and F), despite equivalent mapping efficiency for members of the two subgroups. On average, about half of Class II HERVs, one-third of SVAs, and one-sixth of Class I HERVs marked by TRIM28 in ES cells still...
  7. ...; which in humans includeAlu repeats), or SVAs (SINE-VNTR-Alu, a hominoidspecific ERE family) (de Koning et al. 2011). These genetic invaders, which multiply by the copy-and-paste process that defines retrotransposons, are targeted during the first few days of embryogenesis by silencing mechanisms notably...
  8. ...1 and SVA retrotransposon insertions (;10%) are associated with 39 transduction events, copying various genic elements into new genomic locations (Cordaux and Batzer 2009 and references therein). An interesting recent study provided initial evidence that 39 transduction may have led to the formation...
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