Searching journal content for articles similar to Crabtree et al. 11 (10): 1746.

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  1. ...an oligonucleotide-based approach with a high-density array format (∼385,000 unique probes) is already leading to widespread adoption of this method for high-resolution mapping of DNA breakpoints for larger sized chromosomal rearrangements in tumors and microdeletion syndromes in humans ( Pollack et al. 2002...
  2. ...(cM), and centromere (in yellow) are indicated. ( B ) A physical map. The portions of the 11 BAC contigs covering 34.5 Mb of the chromosome are in orange and the gaps in plain. The physical distance is indicated (Mb). The maps also show a discrepancy of two markers R2502 (3.1 cM) and R2373 (0 c...
  3. ..., the ends will be from different genomic regions. To examine the level of rearrangements within clones, the contig was interrogated with ∼300 markers for inconsistent map results. In addition, all the BACs in the contig also were fingerprinted using high-resolution restriction fragment pattern analysis...
  4. ...with the current refined comparative map of human chromosome 7, even after inflating our estimated average conserved segment size by ∼15% to account for the portion of the chromosome that cannot currently be assigned to a position in mouse (see below). Whether this difference reflects refined mapping data...
  5. ...), some false-positive clones might be positive signals that were carried over from previous hybridizations. A small portion of false-positive clones were adjacent to true positive clones, these might be the result of contamination in the filter preparation process. The clones that mapped to each STS...
  6. ..., Gabra2 and Gabrb1 , has been determined. This high-resolution physical map will provide the basis for functional characterization and sequencing of genes located in this cluster. RESULTS The contig spanning the GABA A receptor genes in the central portion of mouse chromosome 5 was generated...
  7. ...length is 145 Mb of which 20 Mb is heterochromatin; only the euchromatic portion was seeded so the length used is 125 Mb. The physical map of chromosome 10 has 1162 clones picked for sequencing from 23 anchored contigs; there are 3165 seed markers for one per 45 kb and 1287 frameworks (1212 placement...
  8. ....7 Mb of finished sequences and draft sequences of a tiling path of BAC and P1 clones spanning the euchromatic portion of the (Adams et al. 2000).WGS1 and Release 1 were validated by comparison to the available finished genomic sequences and to a BAC-based physical map of the major autosomes (Hoskins et...
  9. ...that contained no unknown sequence gaps and a relatively clean annotation despite the segmentally duplicated Mamu-A genes. The ∼22 kb of gaps within the MHC class I A region of Mmul_10 are near the Mamu-AG genes, indicating some uncertainty about the accuracy of the assembly in that portion of the class I...
  10. .../. An example of a vervet-specific fission (Fig. 2B) shows the results of a cohybridization FISH experiment, with three almost overlapping human BACs from Chromosome 5 mapping within an interval of ∼622 kb. The external BACs (RP11-450M18 and RP11-1115K14) map to CAE Chromosomes 4 and 23, respectively, while...
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